...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Zoological Science >Defective fin regeneration in medaka fish (Oryzias latipes) with hypothyroidism
【24h】

Defective fin regeneration in medaka fish (Oryzias latipes) with hypothyroidism

机译：甲减鱼的甲hypo鱼（Oryzias latipes）的鳍再生不良

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Wild-type medaka are known to have remarkable capabilities of fin, or epimorphic, regeneration. However, a hypothyroid mutant, kamaitachi (kmi), frequently suffers from injury in fins, suggesting an important role of thyroid hormone in fin regeneration. This led us to examine the relationship between thyroid hormone and fin regeneration using medaka as a model. For this, we first set up a medaka experimental system in which the rate of regeneration was statistically analyzed after caudal fin amputation under normal and hypothyroid conditions. As expected, the regeneration of amputated caudal fins was delayed in hypothyroid kmi -/- mutants. We then examined wild-type medaka with thiourea-induced hypothyroidism to evaluate the requirement of thyroid hormone during epimorphic fin regeneration. The results demonstrate that the growth rate of regenerates was much reduced in severely hypothyroid medaka throughout the regeneration period. This reduction in regenerative rate was recovered by exogenous administration of L-thyroxine. The present study is thus the first to report the direct involvement of thyroid hormone in teleost fin regeneration, and provides a basic framework for future molecular and genetic analyses.
机译：已知野生型具有显着的鳍再生或表观再生能力。但是，甲状腺功能低下的突变体kamaitachi（kmi）经常遭受鳍的损伤，这表明甲状腺激素在鳍再生中具有重要作用。因此，我们以medaka为模型研究了甲状腺激素与鳍鳍再生之间的关系。为此，我们首先建立了一个medaka实验系统，在正常和甲状腺功能减退的情况下，对尾鳍截肢后的再生速率进行统计分析。如所预期的，甲状腺功能减退的kmi-/-突变体中截肢尾鳍的再生被延迟。然后，我们研究了硫脲诱导的甲状腺功能减退症的野生型高中，以评估表皮鳍再生期间甲状腺激素的需求。结果表明，在整个再生过程中，严重甲状腺功能减退的高中，再生物的生长速度大大降低。通过外源施用L-甲状腺素可以恢复这种再生率的降低。因此，本研究是第一个报告甲状腺激素直接参与硬骨鱼鳍再生的研究，并为将来的分子和遗传分析提供了基本框架。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号