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首页> 外文期刊>Zoological Science >Structural Regression of the Rat Corpus Luteum of Pregnancy: Relationship with Functional Regression, Apoptotic Cell Death, and the Suckling Stimulus
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Structural Regression of the Rat Corpus Luteum of Pregnancy: Relationship with Functional Regression, Apoptotic Cell Death, and the Suckling Stimulus

机译：大鼠妊娠黄体的结构退化：与功能退化，凋亡细胞死亡和乳头刺激的关系。

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摘要

The nature of the structural regression of the corpus luteum of pregnancy (PCL) was investigated in rats from day 19 of pregnancy (PRG19) through day 6 postpartum (PP6). A pre-partum decrease in tissue weight of the PCL during the last 4 days of pregnancy was apparent (nearly a 40% decrease) and seemed to parallel the fall in plasma progesterone. The PCL in normally lactating rats further experienced a gradual decrease in the postpartum period, but the reduction was significantly slowed by PP6 in non-lactating rats that were forced to wean from the parturient day (PP0). TUNEL analysis revealed that apoptotic cell death in the regressing PCL showed a 3-4 fold increase in signals after parturition (on PP3) but was fairly limited. Instead, luteal steroidogenic cells came to have cytoplasmic vacuoles by PRG21, and vacuoles increased through PP3. A decelerated decrease in PCL weight following forced weaning was potentially reversed by repeated administration of exogenous prolactin (10 IU) twice daily. This study adds evidence that structural regression of the rat PCL 1) starts to occur before the completion of functional regression, 2) involves a modest incidence of TUNEL-reactive apoptosis, and 3) is promoted by the suckling stimulus, presumably through the effects of prolactin.
机译：从妊娠第19天（PRG19）到产后第6天（PP6），研究了大鼠妊娠黄体（PCL）结构退化的性质。在怀孕的最后4天，PCL的组织重量明显减少了产前（减少了近40％），似乎与血浆孕酮的下降平行。正常哺乳期大鼠的PCL进一步经历了产后的逐渐减少，但是在非哺乳期大鼠中，从产后第一天开始断奶（PP0），PP6的降低明显减慢了。 TUNEL分析显示，在分娩后（在PP3上），PCL的凋亡细胞死亡显示信号增加了3-4倍，但受到相当大的限制。相反，黄体类固醇生成细胞在PRG21的作用下具有胞质液泡，在PP3中液泡增加。强制断奶后PCL体重下降的减慢可能通过每天两次外用催乳素（10 IU）的重复给药来逆转。这项研究增加了证据，证明大鼠PCL的结构退化开始于功能退化完成之前; 2）涉及TUNEL反应性细胞凋亡的发生率适中; 3）哺乳刺激促进了PCL的结构退化，大概是由于催乳素。

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