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首页> 外文期刊>Zoological Science >Ledgerline, a Novel Xenopus laevis Gene, Regulates Differentiation of Presomitic Mesoderm During Somitogenesis
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Ledgerline, a Novel Xenopus laevis Gene, Regulates Differentiation of Presomitic Mesoderm During Somitogenesis

机译：Ledgerline，一个新的非洲爪蟾基因，调节早熟中胚层的分化。

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Segmentation of the vertebrate body via the sequential formation of somites is an important process in embryogenesis. This sequential process is governed by the activation and regulation of Notch-related molecular oscillators by fibroblast growth factor and retinoic acid (RA) signaling. In this study, we identified ledgerline, a novel gene of Xenopus laevis expressed specifically in the presomitic mesoderm. Knockdown of ledgerline using antisense morpholino oligonucleotides shifted the developing somite front and altered the expression of genes that regulate molecular oscillation, including Delta2, ESR5, Hairy2a, and Thylacine1. Knockdown of ledgerline also downregulated RALDH-2 expression. Injection of RARalpha-CA, a constitutively active mutant of the RA receptor RARalpha, subsequently reduced the altered Thylacine1 expression. These results strongly suggest that ledgerline is essential for mesodermal RA activity and differentiation of the presomitic mesoderm during Xenopus somitogenesis.
机译：通过体节的连续形成来分割脊椎动物的身体是胚胎发生中的重要过程。此顺序过程受成纤维细胞生长因子和视黄酸（RA）信号传导对Notch相关分子振荡器的激活和调节的控制。在这项研究中，我们确定了账本植物，这是非洲爪蟾的一个新基因，专门在早熟中胚层中表达。使用反义吗啉代寡核苷酸敲低分类帐，转移了发育中的so突前沿并改变了调节分子振荡的基因的表达，包括Delta2，ESR5，Hairy2a和Thylacine1。降低分类帐还下调了RALDH-2表达。注射RARalpha-CA（RA受体RARalpha的组成型活性突变体）随后降低了Thylacine1表达的改变。这些结果强烈表明，账本植物对于非洲爪蟾的体细胞形成过程中的中胚层RA活性和早熟中胚层的分化至关重要。

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