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Transmissibility and mortality impact of epidemic and pandemic influenza, with emphasis on the unusually deadly 1951 epidemic

机译:流行性流感和大流行性流感的传播性和死亡率影响,重点放在异常致命的1951年流行病上

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摘要

There are important gaps in our current understanding of the influenza virus behavior. In particular, it remains unclear why some inter-pandemic seasons are associated with unusually high mortality impact, sometimes comparable to that of pandemics. Here we compare the epidemiological patterns of the unusually deadly 1951 influenza epidemic (A/H1N1) in England and Wales and Canada with those of surrounding epidemic and pandemic seasons, in terms of overall mortality impact and transmissibility. Based on the statistical and mathematical analysis of vital statistics and morbidity epidemic curves in these two countries, we show that the 1951 epidemic was associated with both higher mortality impact and higher transmissibility than the 1957 and 1968 pandemics. Surprisingly in Liverpool, considered the 'epicenter' of the severe 1951 epidemic, the mortality impact and transmissibility even surpassed the 1918 pandemic.
机译:我们目前对流感病毒行为的理解存在重大差距。特别是,尚不清楚为什么某些大流行间季节与异常高的死亡率影响相关,有时甚至与大流行病的影响相当。在这里,我们从总体死亡率影响和传染性的角度,比较了英格兰,威尔士和加拿大异常致命的1951年流感流行病(A / H1N1)与周围流行和大流行季节的流行病学模式。根据这两个国家生命统计数据和发病率曲线的统计和数学分析,我们发现1951年的这种流行与1957年和1968年的大流行相比具有更高的死亡率影响和更高的传播能力。令人惊讶的是,在利物浦被认为是1951年严重流行病的“中心”,其死亡率影响和传播能力甚至超过了1918年的流行病。

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