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首页> 外文期刊>Vaccine >Cross-protective immunity in calves conferred by a DNA adenine methylase deficient Salmonellaenterica serovar Typhimurium vaccine
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Cross-protective immunity in calves conferred by a DNA adenine methylase deficient Salmonellaenterica serovar Typhimurium vaccine

机译：DNA腺嘌呤甲基化酶缺陷型沙门氏菌血清鼠伤寒疫苗赋予小牛的交叉保护免疫

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摘要

The global trend towards intensive livestock production is associated with increased fecal oral pathogen transmission resulting in a high prevalence of Salmonella. Since many pathogenic Salmonella serovars are often endemic to livestock production systems, it is desirable to develop a vaccine that is capable of eliciting immunity to more than one serovar. Here we examined whether immunization with a modified live Salmonella enterica serovar Typhimurium vaccine strain lacking the DNA adenine methylase (Dam) conferred protection in calves against a heterologous S. enterica Dublin challenge. Vaccinated animals challenged with a virulent Dublin strain exhibited a significant attenuation of clinical disease (improved attitude scores and reduced fever and diarrhea) and a concomitant reduction in Dublin fecal shedding and colonization of mesenteric lymph nodes (MLN) compared to non-vaccinated control animals. These data suggest that vaccination with a dam(-) Typhimurium vaccine strain conferred significant cross-protection against clinical disease in cattle attributable to heterologous challenge with Dublin.
机译：集约化畜牧生产的全球趋势与粪便口腔病原体传播的增加有关，导致沙门氏菌的高流行。由于许多致病性沙门氏菌血清型通常是牲畜生产系统所特有的，因此需要开发一种能够引发针对多种血清型的免疫力的疫苗。在这里，我们检查了缺少DNA腺嘌呤甲基化酶（Dam）的改良的活肠沙门氏菌血清型鼠伤寒沙门氏菌疫苗株的免疫接种是否对牛犊产生了针对异源肠炎沙门氏菌都柏林挑战的保护。与未接种疫苗的对照动物相比，接种了毒力的都柏林毒株的疫苗接种的动物表现出临床疾病的显着减弱（态度评分提高，发烧和腹泻减少），都柏林粪便脱落和肠系膜淋巴结定居（MLN）减少。这些数据表明，用dam（-）鼠伤寒疫苗株进行疫苗接种可显着交叉防御牛源于都柏林的异源攻击的临床疾病。

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