Production of recombinant HIV-1/HBV virus-like particles in Nicotiana tabacum and Arabidopsis thaliana plants for a bivalent plant-based vaccine

Greco R; Michel M; Guetard D; Cervantes-Gonzalez M; Pelucchi N; Wain-Hobson S; Sala F; Sala M

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Production of recombinant HIV-1/HBV virus-like particles in Nicotiana tabacum and Arabidopsis thaliana plants for a bivalent plant-based vaccine

机译：在烟草和拟南芥中为基于二价植物的疫苗生产重组HIV-1 / HBV病毒样颗粒

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Human immunodeficiency virus (HIV-1) and hepatitis B virus (HBV) spread via similar transmission pathways, and infection by HBV occurs in up to 32% of HIV-1 cases. Here, we describe the successful expression of novel recombinant HIV-1/HBV virus-like particles (VLPs) in Nicotiana tabacum and Arabidopsis thaliana. The production levels and quality of the recombinant VLPs were comparable in the two plants, showing that parameters intrinsic to the recombinant proteins determined their assembly into VLPs. These heterologous VLPs can be used in a bivalent anti-HIV-1/-HBV vaccine, administrated via ingestion of transgenic plants.

机译：人类免疫缺陷病毒（HIV-1）和乙型肝炎病毒（HBV）通过相似的传播途径传播，在多达32％的HIV-1病例中发生了HBV感染。在这里，我们描述了在烟草和拟南芥中成功表达新型重组HIV-1 / HBV病毒样颗粒（VLP）。两种植物中重组VLP的生产水平和质量相当，表明重组蛋白固有的参数决定了它们组装成VLP的能力。这些异源VLP可用于二价抗HIV-1 / -HBV疫苗，通过摄入转基因植物来施用。

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《Vaccine》 |2007年第49期|共13页
作者
Greco R; Michel M; Guetard D; Cervantes-Gonzalez M; Pelucchi N; Wain-Hobson S; Sala F; Sala M;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
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1. Production of recombinant HIV-1/HBV virus-like particles in Nicotiana tabacum and Arabidopsis thaliana plants for a bivalent plant-based vaccine [J] . Greco R, Michel M, Guetard D, Vaccine . 2007,第49期

机译：在烟草和拟南芥中为基于二价植物的疫苗生产重组HIV-1 / HBV病毒样颗粒
2. Antifungal Activity of Recombinant Class V Chitinases from Nicotiana tabacum and Arabidopsis thaliana [J] . Takayuki Ohnuma, Toki Taira, Tamo Fukamizo Journal of Applied Glycoscience . 2012,第1期

机译：烟草和拟南芥重组V类几丁质酶的抗真菌活性
3. Antifungal Activity of Recombinant Class V Chitinases from Nicotiana tabacum and Arabidopsis thaliana [J] . Takayuki Ohnuma, Toki Taira, Tamo Fukamizo Journal of Applied Glycoscience . 2012,第1期

机译：烟草和拟南芥重组V类几丁质酶的抗真菌活性
4. HIGH TITER PRODUCTION OF HIV-1 VIRUS-LIKE PARTICLES BY CAP-T CELLS [C] . Sonia Gutierrez-Granados, Laura Cervera, Mercedes Segura, Vaccine technology VI . 2016

机译：通过CAP-T细胞高滴度生产HIV-1病毒样颗粒
5. The 4-coumarate:coenzyme A ligases from Nicotiana tabacum and Arabidopsis thaliana: Characterization ofcDNA clones, gene families, recombinant proteins, and antisense transgenic plants [D] . Lee, Diana 1997

机译：烟草和拟南芥的4-香豆酸酯：辅酶A连接酶：cDNA克隆，基因家族，重组蛋白和反义转基因植物的鉴定
6. Specialized binary vector for plant transformation: expression of the Arabidopsis thaliana AHAS gene in Nicotiana tabacum. [O] . N E Olszewski, F B Martin, F M Ausubel 1988

机译：用于植物转化的专门二元载体：拟南芥AHAS基因在烟草中的表达。
7. Antifungal Activity of Recombinant Class V Chitinases from Nicotiana tabacum and Arabidopsis thaliana [O] . Takayuki Ohnuma, Toki Taira, Tamo Fukamizo 2012

机译：来自尼古利亚纳塔巴蟾蜍和拟南芥的重组级V Chitinase的抗真菌活性

Production of recombinant HIV-1/HBV virus-like particles in Nicotiana tabacum and Arabidopsis thaliana plants for a bivalent plant-based vaccine

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