...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >17D yellow fever vaccines: new insights. A report of a workshop held during the World Congress on medicine and health in the tropics, Marseille, France, Monday 12 September 2005
【24h】

17D yellow fever vaccines: new insights. A report of a workshop held during the World Congress on medicine and health in the tropics, Marseille, France, Monday 12 September 2005

机译：17D黄热病疫苗：新见解。 2005年9月12日，星期一在法国马赛举行的世界热带医学与卫生大会期间研讨会的报告

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Yellow fever (YF) is a major health problem in endemic regions of Africa and South America. It also poses a serious health risk to travellers to areas with endemic disease. Currently, there is no effective drug treatment for YF; however, 17D YF vaccines have demonstrated high rates of effectiveness and good safety profiles. This workshop was organized to review key data and issues about YF disease and currently available 17D YF vaccines. Starting with an overview of the current disease epidemiology in Africa and South America and a review of the safety data of 17D YF vaccines, data were then presented demonstrating the genetic stability of multiple production lots of a 17D YF vaccine, the immunological responses of healthy subjects post-vaccination and the long-term immunogenicity of 17D YF vaccines. Finally, the findings of the molecular characterization of 17D YF virus sub-strains recovered from rare, fatal cases of post-vaccination serious adverse events were presented. There was unanimous agreement that current 17D YF vaccines have a highly favourable benefit-risk profile when used in persons at risk of exposure to the YF virus, and that appropriate use of 17D YF vaccines will minimize the occurrence of serious adverse events post-vaccination.
机译：黄热病（YF）是非洲和南美地区的主要健康问题。这也给旅行者到地方病地区带来严重的健康风险。目前，YF尚无有效的药物治疗方法。然而，17D YF疫苗显示出高效率和良好的安全性。举办该研讨会的目的是审查有关YF疾病和当前可用的17D YF疫苗的关键数据和问题。首先概述了非洲和南美当前的疾病流行病学，并回顾了17D YF疫苗的安全性数据，然后提供了证明17D YF疫苗多批生产的遗传稳定性，健康受试者的免疫应答的数据。疫苗接种后以及17D YF疫苗的长期免疫原性。最后，介绍了从罕见，致命的疫苗接种后严重不良事件中回收的17D YF病毒亚株的分子表征发现。一致同意，当前的17D YF疫苗在有接触YF病毒风险的人群中使用时具有高度有利的受益风险特征，并且适当使用17D YF疫苗可以最大程度地减少疫苗接种后严重不良事件的发生。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号