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Experimental use of the attenuated Ehrlichia ruminantium (Welgevonden) vaccine in Merino sheep and Angora goats

机译:在美利奴羊和安哥拉山羊中使用减毒的埃里希氏反刍动物疫苗的实验应用

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摘要

The attenuated Ehrlichia ruminantium (Welgevonden) stock provides protection against a virulent homologous needle challenge in Merino sheep and Boer goats against heartwater. In this study, cryopreserved stabilates were tested for their suitability as a vaccine in Merino sheep. Vaccination did not produce disease and upon challenge with the virulent homologous stock all animals were fully protected. The vaccination protected all except one animal out of 5 challenged 12 months after immunization. The intramuscular route gave better protection than the subcutaneously applied vaccine. The attenuated vaccine was further evaluated in highly susceptible Angora goats. Although the attenuated vaccine showed an unexpectedly high degree of virulence, animals were fully protected against a lethal needle challenge. (c) 2008 Elsevier Ltd. All rights reserved.
机译:减毒的埃里希氏反刍动物(Welgevonden)母液可保护美利奴羊和波尔山羊的强壮同源针头免受心水侵害。在这项研究中,对冷冻保存的稳定剂在美利奴绵羊中作为疫苗的适用性进行了测试。疫苗接种不会产生疾病,并且在用强毒的同源菌种攻击后,所有动物都得到了充分保护。疫苗接种保护了除免疫后12个月攻击的5只动物中的一只动物以外的所有动物。肌内途径比皮下施用疫苗提供更好的保护。在高度易感的安哥拉山羊中进一步评估了减毒疫苗。尽管减毒疫苗显示出出乎意料的高毒力,但可以完全保护动物免受致命的针头攻击。 (c)2008 Elsevier Ltd.保留所有权利。

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