Influenza virus subtype cross-reactivities of haemagglutination inhibitingand virus neutralising serum antibodies induced by infection orvaccination with an ISCOM-based vaccine

Rimmelzwaan GF.; Baars M.; van Beek R.; de Lijster P.; de Jong JC.; Claas

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Influenza virus subtype cross-reactivities of haemagglutination inhibitingand virus neutralising serum antibodies induced by infection orvaccination with an ISCOM-based vaccine

机译：通过基于ISCOM的疫苗的感染或接种诱导的血凝抑制和病毒中和血清抗体的流感病毒亚型交叉反应

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In Order to study the levels of cross-reactivity of the influenza virus-specific antibody response upon infection or vaccination, usually hemagglutination inhibition assays are performed. In the present study post-infection ferret sera and serum samples obtained from cynomolgus macaques which were vaccinated with an ISCOM preparation based on the influenza virus strain A/Netherlands/18/94 (H3N2) were analyzed for cross-reactivity in the hemagglutination inhibition assay and in virus neutralization assays. It was shown that the cross-reactivity of the antibodies induced upon vaccination or infection with influenza virus proved to be more limited in the virus neutralization assay than ill the hemagglutination assay. The strong antibody response induced by vaccination with the ANetherlands/18/94-(H3N2) preparation was shown to be cross-reactive with recent influenza virus strains, which were isolated since 1992, but not with older strains. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 7]

机译：为了研究感染或接种后流感病毒特异性抗体反应的交叉反应水平，通常进行血凝抑制试验。在本研究中，在血凝抑制试验中分析了用基于流感病毒株A /荷兰/ 18/94（H3N2）的ISCOM制剂接种了食蟹猕猴的感染后雪貂血清和血清样品的交叉反应性以及在病毒中和分析中。结果表明，在疫苗中和试验中，与在血凝试验中相比，在疫苗中或流感病毒感染后诱导的抗体的交叉反应性受到更大的限制。由A Netherlands / 18 / 94-（H3N2）疫苗接种引起的强烈抗体反应显示与自1992年以来分离的最新流感病毒株有交叉反应，但与较旧的病毒株没有交叉反应。（C）1999 Elsevier ScienceLtd。保留所有权利。 [参考：7]

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《Vaccine》 |1999年第21期|共5页
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Rimmelzwaan GF.; Baars M.; van Beek R.; de Lijster P.; de Jong JC.; Claas;
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中图分类卫生标准、卫生检查、医药管理;
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1. Influenza virus subtype cross-reactivities of haemagglutination inhibitingand virus neutralising serum antibodies induced by infection orvaccination with an ISCOM-based vaccine [J] . Rimmelzwaan GF., Baars M., van Beek R., Vaccine . 1999,第20a21期

机译：通过基于ISCOM的疫苗的感染或接种诱导的血凝抑制和病毒中和血清抗体的流感病毒亚型交叉反应
2. Protection, systemic IFNgamma, and antibody responses induced by an ISCOM-based vaccine against a recent equine influenza virus in its natural host. [J] . Paillot R, Grimmett H, Elton D, Veterinary Research: A Journal on Animal Infection . 2008,第3期

机译：基于ISCOM的疫苗针对其自然宿主中的最新马流感病毒诱导的保护作用，系统性IFNγ和抗体反应。
3. In elderly persons live attenuated influenza A virus vaccines do not offer an advantage over inactivated virus vaccine in inducing serum or secretory antibodies or local immunologic memory. [J] . D C Powers, L F Fries, B R Murphy, Journal of Clinical Microbiology . 1991,第3期

机译：在老年人中，减毒的甲型流感病毒活疫苗在诱导血清或分泌性抗体或局部免疫记忆方面不优于灭活病毒疫苗。
4. Antibody and IFN-y Responses Induced by a Recombinant Canarypox Vaccine and Challenge Infection With Equine Influenza Virus [C] . Jules Minke, Remain Paillot, Julia Kydd, Annual Convention of the American Association of Equine Practitioners . 2006

机译：通过重组Canarypox疫苗诱导的抗体和IFN-Y响应，并用马流感病毒攻击感染
5. Novel DNA vaccine development against porcine circovirus type 2 and swine influenza virus H1N1 subtype. [D] . Wei, Huiling. 2012

机译：针对猪圆环病毒2型和猪流感病毒H1N1亚型的新型DNA疫苗开发。
6. Evaluation of a Pseudotyped Virus Neutralisation Test for the Measurement of Equine Influenza Virus-Neutralising Antibody Responses Induced by Vaccination and Infection [O] . Rebecca Kinsley, Stéphane Pronost, Manuelle De Bock, 2020

机译：评价疫苗接种和感染诱导的马流感病毒中和抗体应答测量的假型病毒中和试验
7. Evaluation of Influenza Virus A/H3N2 and B Vaccines on the Basis of Cross-Reactivity of Postvaccination Human Serum Antibodies against Influenza Viruses A/H3N2 and B Isolated in MDCK Cells and Embryonated Hen Eggs [O] . Noriko Kishida, Seiichiro Fujisaki, Masaru Yokoyama, 2012

机译：基于MDCK细胞分离的流感病毒A / H3N2和B和胚胎鸡蛋分离的流感病毒抗体的交叉反应性的流感病毒A / H3N2和B疫苗的评价

Influenza virus subtype cross-reactivities of haemagglutination inhibitingand virus neutralising serum antibodies induced by infection orvaccination with an ISCOM-based vaccine

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