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Do recommended high-risk adults benefit from a first influenza vaccination?

机译:建议的高危成年人是否会从首次流感疫苗接种中受益?

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It is unknown whether a first influenza vaccination protects high-risk adults from severe morbidity and mortality during influenza epidemics. As part of the PRISMA nested case-control study, we aimed to evaluate the effectiveness of first-time and repeat influenza vaccinations in adult persons recommended for vaccination aged between 18 and 64 years during the 1999-2000 influenza A epidemic. After adjustments, 69% of hospitalizations for acute respiratory or cardiovascular disease or death were prevented in first-time vaccinees (95% percent confidence interval [95% CI]: 8-90%). The corresponding figure in persons who were vaccinated before was 85% (95% CI: 36-96%). Adult persons with high-risk medical conditions can substantially benefit from a first and repeat influenza vaccination prior to an epidemic.
机译:尚不知道首次流感疫苗接种能否在流感流行期间保护高危成年人免于严重的发病率和死亡率。作为PRISMA嵌套病例对照研究的一部分,我们旨在评估在1999-2000年甲型流感流行期间建议初次接种和重复接种流感疫苗的成年人在18至64岁之间接种疫苗的有效性。调整后,首次使用疫苗预防了69%的急性呼吸道或心血管疾病或死亡住院(95%的置信区间[95%CI]:8-90%)。之前接种疫苗的人的这一数字是85%(95%CI:36-96%)。具有高风险医疗条件的成年人可以从流行之前的第一次和重复的流感疫苗中大量受益。

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