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Vaccine potential of novel surface exposed and secreted proteins of Streptococcus equi

机译：马链球菌新型表面暴露和分泌蛋白的疫苗潜力

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摘要

Streptococcus equi, a clonal descendent of an ancestral S. zooepidemicus, causes equine strangles, a highly contagious purulent lymphadenitis of the head and neck. The aim of this study was to evaluate as vaccine components novel surface exposed or secreted S. equi proteins identified in an expression gene library with sera from resistant horses. Six proteins expressed by S. equi CF32 but not by S. zooepidemicus 631 were used to vaccinate one group of eight ponies. A second pony group was immunized with five adhesin and other proteins encoded by genes of Linkage Gr 1. All ponies made strong serum antibody responses to each protein as measured by ELISA but none were resistant to subsequent comingling challenge with S. equi CF32. These results in combination with evidence that recovered horses rapidly clear intranasally inoculated S. equi and do not make detectable serum antibody responses to its surface proteins suggest that acquired immune-mediated tonsillar clearance and not serum antibody must be stimulated by an effective strangles vaccine.
机译：马链球菌是祖先兽疫链球菌的克隆后代，会引起马勒死，是一种高度传染性的头颈部脓性淋巴结炎。这项研究的目的是评估表达基因库中鉴定出的新的表面暴露或分泌的马链球菌蛋白作为疫苗成分，该蛋白具有抗性马的血清。用马链球菌CF32表达的六种蛋白而非兽疫链球菌631表达的六种蛋白接种一组八个小马。第二个小马群用五种粘附素和由Linkage Gr 1基因编码的其他蛋白质免疫。通过ELISA测定，所有小马对每种蛋白质均产生强烈的血清抗体反应，但没有一个对随后的马链球菌CF32混合攻击产生抗性。这些结果与恢复的马迅速清除鼻内接种的马链球菌并且没有对其表面蛋白产生可检测的血清抗体反应的证据相结合，表明必须通过有效的勒死疫苗刺激获得的免疫介导的扁桃体清除，而不是血清抗体。

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