C57Bl/6 mice are protected from respiratory syncytial virus (RSV) challenge and IL-5 associated pulmonary eosinophilic infiltrates following intranasal immunization with Protollin-eRSV vaccine

Cyr SL; Jones T; Stoica-Popescu I; Burt D; Ward BJ

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C57Bl/6 mice are protected from respiratory syncytial virus (RSV) challenge and IL-5 associated pulmonary eosinophilic infiltrates following intranasal immunization with Protollin-eRSV vaccine

机译：用Protollin-eRSV疫苗鼻内免疫后，可保护C57Bl / 6小鼠免于呼吸道合胞病毒（RSV）攻击和IL-5相关的肺嗜酸性粒细胞浸润

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The protective efficacy of an intranasal (IN) Protollin-eRSV vaccine has recently been demonstrated in the RSV-susceptible BALB/c mouse model. Here, we report the safety, immunogenicity and efficacy of Protollin-eRSV vaccine in the relatively resistant C57Bl/6 mouse model. C57Bl/6 mice immunized IN with either two or three doses of Protollin-eRSV produced significant systemic and mucosal RSV-specific antibodies. Mice immunized with the Protollin vaccine displayed polarized Th1 responses with augmented IFNgamma/IL-5 ratios in RSV-restimulated lung and spleen cell preparations compared with animals that received antigen alone. The Protollin-eRSV immunized C57Bl/6 mice were fully protected against challenge without eosinophilic pulmonary pathology observed in the animals immunized with the formalin-inactivated RSV vaccine. This new model will permit us to dissect the respective roles of the TLR2 and TLR4 ligands contained in the vaccine using TLR knock-out animals established on the C57Bl/6 background.

机译：鼻内（IN）Protollin-eRSV疫苗的保护功效最近在对RSV敏感的BALB / c小鼠模型中得到了证实。在这里，我们报告了Protollin-eRSV疫苗在相对耐药的C57Bl / 6小鼠模型中的安全性，免疫原性和功效。用两剂或三剂Protollin-eRSV免疫IN的C57Bl / 6小鼠产生了明显的全身性和粘膜RSV特异性抗体。与仅接受抗原的动物相比，用Protollin疫苗免疫的小鼠在RSV重新刺激的肺和脾细胞制剂中表现出极化的Th1反应，并具有增加的IFNgamma / IL-5比。在用福尔马林灭活的RSV疫苗免疫的动物中未观察到嗜酸性的肺病理学的情况下，对Protollin-eRSV免疫的C57Bl / 6小鼠进行了充分的保护，免受攻击。这种新模型将使我们能够使用在C57Bl / 6背景上建立的TLR基因敲除动物来剖析疫苗中所含的TLR2和TLR4配体的各自作用。

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《Vaccine》 |2007年第16期|共5页
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Cyr SL; Jones T; Stoica-Popescu I; Burt D; Ward BJ;
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中图分类卫生标准、卫生检查、医药管理;
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1. C57Bl/6 mice are protected from respiratory syncytial virus (RSV) challenge and IL-5 associated pulmonary eosinophilic infiltrates following intranasal immunization with Protollin-eRSV vaccine [J] . Cyr SL, Jones T, Stoica-Popescu I, Vaccine . 2007,第16期

机译：用Protollin-eRSV疫苗鼻内免疫后，可保护C57Bl / 6小鼠免于呼吸道合胞病毒（RSV）攻击和IL-5相关的肺嗜酸性粒细胞浸润
2. An insect cell derived respiratory syncytial virus (RSV) F nanoparticle vaccine induces antigenic site II antibodies and protects against RSV challenge in cotton rats by active and passive immunization [J] . Vaccine . 2014,第48期

机译：一种昆虫细胞源呼吸道合胞病毒（RSV）F纳米颗粒疫苗可通过主动和被动免疫诱导棉鼠的抗原性II位抗体并防御RSV攻击
3. Maternal immunization with RSV fusion glycoprotein vaccine and substantial protection of neonatal baboons against respiratory syncytial virus pulmonary challenge [J] . Vaccine . 2020,第5期

机译：用RSV融合糖蛋白疫苗母体免疫疫苗和对新生儿狒狒进行了大量保护对抗呼吸道同性恋病毒肺挑战
4. Synthesis and refolding of G20,a potential antigen for human Respiratory Syncytial Virus (hRSV) vaccine [C] . Christine Klinguer-Hamour, Marie-Claire Bussat, Helene Plotnicky-Gilquin, European Peptide Symposium . 2002

机译：G20的合成和重折叠，人类呼吸合胞病毒（HRSV）疫苗的潜在抗原
5. Regulation of respiratory syncytial virus (RSV) vaccine-enhanced pulmonary eosinophilia [D] . Olson, Matthew Richard 2008

机译：呼吸道合胞病毒（RSV）疫苗增强的肺嗜酸性粒细胞增多症的调节
6. An insect cell derived respiratory syncytial virus (RSV) F nanoparticle vaccine induces antigenic site II antibodies and protects against RSV challenge in cotton rats by active and passive immunization [O] . Rama Raghunandan, Hanxin Lu, Bin Zhou, -1

机译：昆虫细胞源呼吸道合胞病毒（RSV）F纳米颗粒疫苗可通过主动和被动免疫诱导棉鼠的抗原性II位抗体并防御RSV攻击
7. An insect cell derived respiratory syncytial virus (RSV) F nanoparticle vaccine induces antigenic site II antibodies and protects against RSV challenge in cotton rats by active and passive immunization [O] . Raghunandan Rama, Lu Hanxin, Zhou Bin, 2014

机译：昆虫细胞来源的呼吸道合胞病毒（RSV）F纳米颗粒疫苗可通过主动和被动免疫诱导棉鼠的抗原性II位抗体并防御RSV攻击
8. Smallpox DNA Vaccine Delivered by Novel Skin Electroporation Device Protects Mice Against Intranasal Poxvirus Challenge [R] . Hooper, J. W. , Golden, J. W. , Ferro, A. M. , 2006

机译：新型皮肤电穿孔装置提供的天花DNa疫苗可保护小鼠免受鼻内痘病毒的挑战

C57Bl/6 mice are protected from respiratory syncytial virus (RSV) challenge and IL-5 associated pulmonary eosinophilic infiltrates following intranasal immunization with Protollin-eRSV vaccine

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