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首页> 外文期刊>Vaccine >Direct effect of Plasmodium vivax recombinant vaccine candidates AMA-1 and MSP-1(19) on the innate immune response
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Direct effect of Plasmodium vivax recombinant vaccine candidates AMA-1 and MSP-1(19) on the innate immune response

机译：间日疟原虫重组疫苗候选物AMA-1和MSP-1（19）对先天免疫应答的直接影响

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摘要

The recombinant apical membrane antigen 1 (AMA-1) and 19-kDa fragment of merozoite surface protein (MSP-1(19)) are the lead candidates for inclusion in a vaccine against blood stages of malaria due to encouraging protective studies in humans and animals. Despite the importance of an efficacious malaria vaccine, vaccine-related research has focused on identifying antigens that result in protective immunity rather than determining the nature of anti-malarial immune effector mechanisms. Moreover, emphasis has been placed on adaptive rather than innate immune responses. In this study, we investigated the effect of Plasmodium vivax vaccine candidates Pv-AMA-1 and Pv-MSP-1(19) on the immune response of malaria-naive donors. Maturation of dendritic cells is altered by Pv-AMA-1 but not Pv-MSP-1(19), as observed by differential expression of cell surface markers. In addition, Pv-AMA-1 induced an increased production of MIP-1alpha/CCL3 and decreased production of TARC/CCL17 levels in both dendritic cells (DCs) and peripheral blood mononuclear cells (PBMCs). Finally, a significant pro-inflammatory response was elicited by Pv-AMA-1-stimulated PBMCs. These results suggest that the recombinant vaccine candidate Pv-AMA-1 may play a direct role on innate immune response and might be involved in parasite destruction.
机译：重组人顶膜抗原1（AMA-1）和裂殖子表面蛋白的19 kDa片段（MSP-1（19））由于对人类和人类的保护性研究令人鼓舞，因此是抗疟疾疫苗中的主要候选药物。动物。尽管有效的疟疾疫苗很重要，但与疫苗相关的研究集中在鉴定导致保护性免疫的抗原上，而不是确定抗疟疾免疫效应子机制的性质。而且，重点已放在适应性免疫应答而非先天免疫应答上。在这项研究中，我们调查了间日疟原虫疫苗候选Pv-AMA-1和Pv-MSP-1（19）对未接受疟疾的捐助者的免疫反应的影响。如通过细胞表面标志物的差异表达所观察到的，树突状细胞的成熟受到Pv-AMA-1的改变，而不受Pv-MSP-1（19）的改变。此外，Pv-AMA-1诱导树突状细胞（DC）和外周血单核细胞（PBMC）中MIP-1alpha / CCL3的产量增加，而TARC / CCL17的产量下降。最后，Pv-AMA-1刺激的PBMC引发了明显的促炎反应。这些结果表明重组疫苗候选Pv-AMA-1可能对先天免疫应答起直接作用，并可能参与寄生虫破坏。

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