Lessons learned from clinical trials evaluating pneumococcal conjugate vaccine efficacy against pneumonia and invasive disease.

Madhi SA; Whitney CG; Nohynek H

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Lessons learned from clinical trials evaluating pneumococcal conjugate vaccine efficacy against pneumonia and invasive disease.

机译：从评估肺炎球菌结合疫苗抗肺炎和侵袭性疾病功效的临床试验中学到的经验教训。

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This article discusses lessons learned from clinical trials with pneumococcal conjugate vaccines (PCVs). A review of major clinical trials investigating PCV efficacy, this article provides the context to explore challenges associated with studying pneumococcal pneumonia and vaccine efficacy, particularly related to non-bacteremic disease, serotypes, and radiograph interpretation. Throughout these clinical trials, improving the pneumonia diagnosis specificity increased vaccine efficacy estimates. Additional analysis suggests this improvement may come at a cost of detecting much less of the disease burden. The article concludes with a discussion of the potential value of C-reactive protein as an adjunctive marker in measuring PCV efficacy against non-bacteremic pneumococcal pneumonia.

机译：本文讨论了肺炎球菌结合疫苗（PCV）从临床试验中学到的经验教训。本文综述了研究PCV功效的主要临床试验，为探索与研究肺炎球菌性肺炎和疫苗功效相关的挑战提供了背景，特别是与非细菌性疾病，血清型和X线片解释有关的挑战。在整个这些临床试验中，改善肺炎的诊断特异性可提高疫苗功效的估计值。进一步的分析表明，这种改善可能以检测到更少的疾病负担为代价。文章最后讨论了C反应蛋白作为辅助标记物在测量PCV对非细菌性肺炎球菌性肺炎的疗效中的潜在价值。

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《Vaccine》 |2008年第2期|共7页
作者
Madhi SA; Whitney CG; Nohynek H;
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正文语种 eng
中图分类医学免疫学;
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1. Lessons learned from clinical trials evaluating pneumococcal conjugate vaccine efficacy against pneumonia and invasive disease. [J] . Madhi SA, Whitney CG, Nohynek H Vaccine . 2008,第Suppla2期

机译：从评估肺炎球菌结合疫苗抗肺炎和侵袭性疾病功效的临床试验中学到的经验教训。
2. Evaluation of a phased pneumococcal conjugate vaccine introduction in Mongolia using enhanced pneumonia surveillance and community carriage surveys: a study protocol for a prospective observational study and lessons learned [J] . S. F. La Vincente, C. von Mollendorf, M. Ulziibayar, BMC Public Health . 2019,第1期

机译：评估蒙古术中临床肺炎球菌共轭疫苗疫苗使用增强的肺炎监测和社区运输调查：一个潜在观察研究和经验教训的研究议定书
3. Efficacy of nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in The Gambia: randomised, double-blind, placebo-controlled trial. [J] . Cutts FT, Zaman SM, Enwere G, The Lancet . 2005,第9465期

机译：冈比亚9价肺炎球菌结合疫苗对肺炎和侵袭性肺炎球菌疾病的疗效：随机，双盲，安慰剂对照试验。
4. Development of a Streptococcus pneumoniae conjugate vaccine against serotype 1 disease. [C] . Edmonds-Smith. C., Mohamed E., Wilson S. International Carbohydrate Symposium . 2013

机译：肺炎链球菌伴血管型1肝炎疫苗的发展。
5. Impact of Pneumococcal Conjugate Vaccine Thirteen Valent on the Reduction of Invasive Pneumococcal Disease. [D] . Coulibaly, Aissata. 2016

机译：肺炎球菌结合疫苗十三价对减少侵袭性肺炎球菌疾病的影响。
6. Evaluation of a phased pneumococcal conjugate vaccine introduction in Mongolia using enhanced pneumonia surveillance and community carriage surveys: a study protocol for a prospective observational study and lessons learned [O] . S. F. La Vincente, C. von Mollendorf, M. Ulziibayar, 1944

机译：使用增强的肺炎监测和社区运输调查评估蒙古分阶段引入的肺炎球菌结合疫苗：一项前瞻性观察研究的研究方案和经验教训
7. A post-hoc analysis of serotype-specific vaccine efficacy of 13-valent pneumococcal conjugate vaccine against clinical community acquired pneumonia from a randomized clinical trial in the Netherlands [O] . Bradford D. Gessner, Qin Jiang, Cornelis H. Van Werkhoven, 2019

机译：HOC型血管型疫苗疫苗对临床群落的血清型疫苗疫苗对荷兰随机临床试验中的肺炎群岛疫苗疫苗的特异性疫苗疗效。从荷兰的随机临床试验中获得肺炎

Lessons learned from clinical trials evaluating pneumococcal conjugate vaccine efficacy against pneumonia and invasive disease.

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