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首页> 外文期刊>Vaccine >Long-term antibody persistence in children primed and boosted with a DTPw-HBV vaccine at 2, 4, 6, 18, months of age.
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Long-term antibody persistence in children primed and boosted with a DTPw-HBV vaccine at 2, 4, 6, 18, months of age.

机译：用DTPw-HBV疫苗在2、4、6、18个月大时可以激发和加强儿童的长期抗体持久性。

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This paper presents 7- and 10-year follow-up immunogenicity data from two studies, which explored long-term persistence induced by combined tetravalent DTPw-HBV vaccines. The 10-year follow-up study compared two identical antigen-content, but different formulations of DTPw-HBV vaccine (adsorbed on either Al(OH)(3) or Al(PO(4)), whilst the 7-year follow-up study compared two different formulations of DTPw-HBV vaccines containing 5 and 10mug of hepatitis B surface antigen (HBsAg), following a birth dose of HBV. Primary vaccination took place at 2, 4, 6 months and booster dosing at 18 months. A booster dose of local DTPw vaccine was given at 4 years of age to all returning subjects. At the end of the 7-year study, 90.9% subjects receiving 10mug HBsAg had anti-HBs antibody concentrations >/=10mIU/ml; the majority of subjects remained seroprotected against diphtheria and tetanus (>/=90.9 and 100%, respectively) and 100% had seropositive levels for pertussis antigens. At the end of the 10-year follow-up study, >/=60.9% subjects had seroprotective concentrations of anti-HBs antibodies; >/=95.2 and 100% subjects were seroprotected against diphtheria and tetanus, respectively; >/=78.3% subjects were seropositive for pertussis. The results demonstrate long-term antibody persistence induced by combined DTPw-HBV vaccine.
机译：本文提供了两项研究的7年和10年随访免疫原性数据，这些数据探讨了联合四价DTPw-HBV疫苗诱导的长期持久性。这项为期10年的随访研究比较了两种相同的抗原含量，但DTPw-HBV疫苗的配方不同（分别吸附在Al（OH）（3）或Al（PO（4））上），而7年的随访结果是：一项向上的研究比较了两种不同的DTPw-HBV疫苗制剂，它们分别在出生剂量的HBV后含有5和10杯的乙型肝炎表面抗原（HBsAg），分别在第2、4、6个月和18个月时进行加强免疫。在4岁时，对所有返回的受试者都给予了局部DTPw疫苗的加强剂量;在7年研究结束时，接受10杯HBsAg的90.9％受试者的抗HBs抗体浓度> / = 10mIU / ml;大多数受试者对白喉和破伤风保持血清保护（分别为> / = 90.9和100％），百日咳抗原的血清反应阳性水平为100％;在10年随访研究结束时，> / = 60.9％的受试者具有血清保护浓度抗-HBs抗体;> / = 95.2，并且100％的受试者血清白喉和破伤风的血清保护， 分别; > / = 78.3％的受试者对百日咳呈血清反应阳性。结果证明了由联合DTPw-HBV疫苗诱导的长期抗体持久性。

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