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Vaccination and antigenic drift in influenza.

机译：流感疫苗和抗原性漂移。

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The relationship between influenza antigenic drift and vaccination lies at the intersection of evolutionary biology and public health, and it must be viewed and analyzed in both contexts simultaneously. In this paper, 1 review what is known about the effects of antigenic drift on vaccination and the effects of vaccination on antigenic drift, and I suggest some simple ways to detect the presence of antigenic drift in seasonal influenza data. If antigenic drift occurs on the time scale of a single influenza season, it may be associated with the presence of herd immunity at the beginning of the season and may indicate a need to monitor for vaccine updates at the end of the season. The relationship between antigenic drift and vaccination must also be viewed in the context of the global circulation of influenza strains and the seeding of local and regional epidemics. In the data sets I consider--from New Zealand, New York, and France--antigenic drift can be statistically detected during some seasons, and seeding of epidemics appears to be endogenous sometimes and exogenous at other times. Improved detection of short-term antigenic drift and epidemic seeding would significantly benefit influenza monitoring efforts and vaccine selection.
机译：流感抗原漂移与疫苗接种之间的关系在于进化生物学与公共卫生的交叉点，必须同时在两种情况下对其进行观察和分析。在本文中，1回顾了关于抗原漂移对疫苗接种的影响以及疫苗接种对抗原漂移的影响的知识，我提出了一些简单的方法来检测季节性流感数据中抗原漂移的存在。如果抗原漂移发生在单个流感季节的时间范围内，则可能与该季节开始时牛群免疫的存在有关，并且可能表明需要在该季节结束时监视疫苗更新。还必须在全球流行的流感病毒株以及地方和区域流行病播种的背景下，观察抗原性漂移与疫苗接种之间的关系。在我认为来自新西兰，纽约和法国的数据集中，可以在某些季节统计地检测到抗原漂移，流行病的播种有时是内源的，有时是外源的。改进的短期抗原漂移和流行病播种检测将大大有利于流感监测工作和疫苗选择。

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