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首页> 外文期刊>Vaccine >Enhancement of the CD8(+) T cell response to a subdominant epitope of respiratory syncytial virus by deletion of an immunodominant epitope.
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Enhancement of the CD8(+) T cell response to a subdominant epitope of respiratory syncytial virus by deletion of an immunodominant epitope.

机译：通过删除免疫显性表位，增强对呼吸道合胞病毒亚表位的CD8（+）T细胞应答。

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摘要

Cytotoxic T lymphocytes (CTLs) are critical for the control of respiratory syncytial virus infection (RSV) in humans and mice. Recently, we identified a new H-2K(d)-restricted subdominant epitope in the respiratory syncytial virus M2 protein. In this study, we investigated if modification of anchor residues at positions 2 and 9 in the dominant M2(82-90) epitope in the M2 protein would alter the CTL epitope dominance hierarchy following immunization with plasmid DNA encoding M2 proteins. We showed that immunogenicity of the subdominant epitope M2(127-135) was enhanced when the anchor residues of the dominant epitope were mutated, suggesting that the immunodominant epitope induces a suppression of response to the subdominant epitope.
机译：细胞毒性T淋巴细胞（CTL）对于控制人类和小鼠的呼吸道合胞病毒感染（RSV）至关重要。最近，我们在呼吸道合胞病毒M2蛋白中发现了一个新的H-2K（d）限制性亚基表位。在这项研究中，我们调查了用编码M2蛋白的质粒DNA免疫后，M2蛋白中显性M2（82-90）表位2和9位锚残基的修饰是否会改变CTL表位优势层次。我们表明当显性表位的锚定残基发生突变时，显性表位M2（127-135）的免疫原性得到增强，这表明免疫显性表位诱导了对显性表位的应答抑制。

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