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首页> 外文期刊>Vaccine >Traitors of the immune system-Enhancing antibodies in HIV infection: Their possible implication in HIV vaccine development.
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Traitors of the immune system-Enhancing antibodies in HIV infection: Their possible implication in HIV vaccine development.

机译：HIV感染中增强免疫系统的抗体的弊端：它们对HIV疫苗开发的潜在影响。

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Considering recent HIV vaccine failures, the authors believe that it would be most important to find new targets for vaccine-induced immunity, and to analyze the data from previous trials, using an innovative approach. In their review article, the authors briefly summarize the significance of the antibody-dependent enhancement of infection in different viral diseases and discuss role of these types of antibodies as the obstacles for vaccine development. Findings which indicate that complement-mediated antibody-dependent enhancement (C-ADE) is present also in HIV-infected patients, are summarized. Previous results of the authors, suggesting that C-ADE plays a very important role in the progression of HIV infection are described. Data reflecting that enhancing antibodies may develop even in vaccinated animals and human volunteers, and may be responsible for the paradoxical results obtained in some subgroups of vaccinees are discussed. Finally, based on their hypothesis, the authors offer some suggestions for the future development of vaccines.
机译：考虑到最近的HIV疫苗失败，作者认为最重要的是找到新的疫苗诱导免疫靶点，并使用创新方法分析以前试验的数据。在他们的综述文章中，作者简要总结了抗体依赖性增强感染在不同病毒性疾病中的重要性，并讨论了这类抗体作为疫苗开发障碍的作用。总结了表明HIV感染的患者中也存在补体介导的抗体依赖性增强作用（C-ADE）的发现。作者的先前结果表明，C-ADE在HIV感染的进展中起着非常重要的作用。讨论了反映增强抗体甚至可能在接种疫苗的动物和人类志愿者中产生的数据，并且可能与某些疫苗亚组中获得的矛盾结果有关。最后，基于他们的假设，作者为疫苗的未来发展提供了一些建议。

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