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首页> 外文期刊>Vaccine >Epidemiological serosurvey of Hepatitis B in China-Declining HBV prevalence due to Hepatitis B vaccination
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Epidemiological serosurvey of Hepatitis B in China-Declining HBV prevalence due to Hepatitis B vaccination

机译：中国乙型肝炎的流行病学调查-乙型肝炎疫苗接种引起的HBV流行率下降

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Objective: To determine the prevalence of hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core anti-body(anti-HBc) in a representative population in China 14 years after introduction of hepatitis B vaccination of infants.Methods: National serosurvey, with participants selected by multi-stage random sampling. Demographics and hepatitis B vaccination history collected by questionnaire and review of vaccination records, and serum tested for HBsAg, antibody to anti-HBc and anti-HBs by ELISA.Findings: The weighted prevalences of HBsAg, anti-HBs and anti-HBc for Chinese population aged 1-59 years were 7.2%, 50.1%, 34.1%, respectively. HBsAg prevalence was greatly diminished among those age <15 years compared to that found in the 1992 national serosurvey, and among children age <5 years was only 1.0% (90% reduction). Reduced HBsAg prevalence was strongly associated with vaccination among all age groups. HBsAg risk in adults was associated with male sex, Western region, and certain ethnic groups and occupations while risk in children included birth at home or smaller hospitals, older age, and certain ethnic groups (Zhuang and other).Conclusions: China has already reached the national goal of reducing HBsAg prevalence to less than 1% among children under 5 years and has prevented an estimated 16-20 million HBV carriers through hepatitis B vaccination of infants. Immunization program should be further strengthened to reach those remaining at highest risk. (C) 2009 Elsevier Ltd. All rights reserved.
机译：目的：确定乙型肝炎感染后14年的代表性人群中乙型肝炎表面抗原（HBsAg），乙型肝炎表面抗体（抗HBs）和乙型肝炎核心抗体（anti-HBc）的患病率方法：国家血清调查，参加者通过多阶段随机抽样选择。通过问卷调查和疫苗接种记录的回顾收集人口和乙肝疫苗接种史，并通过ELISA检测血清的HBsAg，抗HBc和抗HBs抗体发现：中国人HBsAg，抗HBs和抗HBc的加权患病率1-59岁的人口分别为7.2％，50.1％和34.1％。与1992年全国血清学调查相比，在15岁以下的人群中HBsAg的患病率大大降低，在5岁以下的儿童中HBsAg的患病率仅为1.0％（降低了90％）。在所有年龄段中，HBsAg流行率降低均与疫苗接种密切相关。成人的HBsAg风险与男性，西部地区以及某些种族和职业相关，而儿童的HBsAg风险包括在家中或较小医院出生，年龄较大和某些种族（壮族和其他种族）的儿童。结论：中国已经达到全国目标是将5岁以下儿童的HBsAg感染率降低至1％以下，并通过婴儿乙肝疫苗接种预防了约16-20百万HBV携带者。应当进一步加强免疫计划，以使那些仍处于最高风险的人受益。 （C）2009 Elsevier Ltd.保留所有权利。

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