RepliVAX WN, a single-cycle flavivirus vaccine to prevent West Nile disease, elicits durable protective immunity in hamsters.

Widman D. G.; Ishikawa T.; Winkelmann E. R.; Infante E.; Bourne N.; Mason P. W.

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RepliVAX WN, a single-cycle flavivirus vaccine to prevent West Nile disease, elicits durable protective immunity in hamsters.

机译：RepliVAX WN是一种预防西尼罗河疾病的单周期黄病毒疫苗，可引起仓鼠持久的保护性免疫。

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West Nile virus (WNV) causes significant disease, yet no vaccines exist to prevent WN disease in humans. We have previously reported that RepliVAX WN is a safe and efficacious vaccine in mouse and hamster models of WN disease. Here, we report that vaccination of hamsters with RepliVAX WN induces antibody responses that remain stable for at least 6 months. Furthermore, animals challenged with virulent WNV 6 months after vaccination were protected from disease as well as those challenged 2 months post-vaccination, with no vaccinated animals succumbing to WNV challenge. These results indicate that RepliVAX is capable of inducing durable protective immunity after a single dose.

机译：西尼罗河病毒（WNV）引起重大疾病，但尚无预防人类WN疾病的疫苗。我们以前曾报道过，RepliVAX WN在WN疾病的小鼠和仓鼠模型中是一种安全有效的疫苗。在这里，我们报告说，用RepliVAX WN注射仓鼠疫苗可诱导至少6个月保持稳定的抗体反应。此外，接种疫苗后6个月受到强力WNV攻击的动物以及接种疫苗后2个月受到攻击的动物均得到了保护，而没有疫苗接种的动物死于WNV攻击。这些结果表明，RepliVAX能够在单剂后诱导持久的保护性免疫。

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来源
《Vaccine》 |2009年第41期|共4页
作者
Widman D. G.; Ishikawa T.; Winkelmann E. R.; Infante E.; Bourne N.; Mason P. W.;
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正文语种 eng
中图分类预防医学、卫生学;
关键词
animal models; disease prevention; immune response; immunity; immunization; laboratory animals; vaccination; vaccines; West Nile fever; Flavivirus; hamsters; West Nile virus;

机译：动物模型;疾病预防;免疫应答;免疫;免疫;实验室动物;疫苗接种;疫苗;西尼罗河热;黄病毒;仓鼠;西尼罗河病毒;

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1. RepliVAX WN, a single-cycle flavivirus vaccine to prevent West Nile disease, elicits durable protective immunity in hamsters. [J] . Widman D. G., Ishikawa T., Winkelmann E. R., Vaccine . 2009,第41期

机译：RepliVAX WN是一种预防西尼罗河疾病的单周期黄病毒疫苗，可引起仓鼠持久的保护性免疫。
2. Immunogenicity of RepliVAX WN, a novel single-cycle West Nile virus vaccine [J] . Nelson Michelle H., Winkelmann Evandro, Ma Yinghong, Vaccine . 2010,第2期

机译：新型单周期西尼罗河病毒疫苗RepliVAX WN的免疫原性
3. Vero cell-derived inactivated West Nile (WN) vaccine induces protective immunity against lethal WN virus infection in mice and shows a facilitated neutralizing antibody response in mice previously immunized with Japanese encephalitis vaccine. [J] . Lim CK, Takasaki T, Kotaki A, Virology . 2008,第1期

机译：Vero细胞衍生的灭活西尼罗河（WN）疫苗在小鼠中诱导了针对致命WN病毒感染的保护性免疫，并在先前用日本脑炎疫苗免疫的小鼠中显示出促进的中和抗体反应。
4. Evaluation of Immune Responses in Foals Post-Vaccination With a West Nile Virus Vaccine (Live Flavivirus Chimera) [C] . Cynthia V. Gutierrez, Stuart E. Brown II, Maureen T. Long, Annual Convention of the American Association of Equine Practitioners . 2008

机译：用西尼罗河病毒疫苗（Live Flavivirus Chimera）的疫苗接种后免疫应答评价
5. Conformation Matters: Immunity Elicited by the Stabilized Pre-fusion F Subunit Vaccine DS-Cav1 Is Potent and Durable [D] . Phung, Emily. 2021

机译：构象事项：通过稳定的预熔融F亚单位疫苗DS-CAV1引发的免疫力是有效的和耐用的
6. TLR3- and MyD88-Dependent Signaling Differentially Influences the Development of West Nile Virus-Specific B Cell Responses in Mice following Immunization with RepliVAX WN a Single-Cycle Flavivirus Vaccine Candidate [O] . Jingya Xia, Evandro R. Winkelmann, Summer R. Gorder, 2013

机译：TLR3和MyD88依赖信号差异影响RepliVAX WN单周期黄病毒疫苗候选者免疫后小鼠西尼罗河病毒特异性B细胞反应的发展。
7. Evaluation of RepliVAX WN, a Single-Cycle Flavivirus Vaccine, in a Non-Human Primate Model of West Nile Virus Infection [O] . Widman, Douglas G., Ishikawa, Tomohiro, Giavedoni, Luis D., 2010

机译：西尼罗河病毒感染的非人类灵长类动物模型中的单周期黄病毒疫苗RepliVAX WN的评估。
8. Multi-Agent Alphavirus DNA Vaccine Delivered by Intramuscular Electroporation Elicits Robust and Durable Virus Specific Immune Responses in Mice and Rabbits and Completely Protects Mice against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenges. [R] . Dupuy, L. C., Richards, M. J., Livingston, B. D., 2016

机译：通过肌内电穿孔提供的多剂甲病毒DNa疫苗在小鼠和家兔中引发健壮和耐久的病毒特异性免疫应答，并完全保护小鼠免受致命的委内瑞拉，西方和东方马脑炎病毒气溶胶挑战。

RepliVAX WN, a single-cycle flavivirus vaccine to prevent West Nile disease, elicits durable protective immunity in hamsters.

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