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Human papillomavirus genotypes and phylogenetic analysis of HPV-16 variants in HIV-1 infected subjects in Italy

机译:意大利感染HIV-1的人乳头瘤病毒基因型和HPV-16变异的系统发育分析

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摘要

A cross-sectional study was carried out to improve the state of evidence regarding the spectrum of HPV types and HPV-16 LCR variants circulating among men and women infected with HIV-1 in Italy. This study, conducted in 518 HIV-positive subjects (346males and 172 females), showed a high prevalence of HPV anal infections (88.7%) in men and of cervical infections (65.1%) in women.A wide spectrum of HPV genotypes has been observed, as both single and multiple infections. Low-risk HPV types 6,11 and 61 were frequently detected. HPV-16 was the prevalent high-risk type. Fourteen different HPV-16 LCR variants were found. Ten belongedto the European lineage (78.7% were detected in Italian subjects and 21.3% in foreign-born, all homo/bisexual men), two to the Asiatic lineage and two to the African-2 lineage. This study underlines the great genotypic heterogeneity characterizing anal and cervical HPV infections and the marked polymorphism of the predominant HPV-16 in this high-risk population in Italy.
机译:进行了一项横断面研究,以改善有关在意大利感染HIV-1的男女之间传播的HPV类型和HPV-16 LCR变异谱的证据。这项研究在518名HIV阳性受试者(346名男性和172名女性)中进行,显示男性中HPV肛门感染率高(88.7%),女性中宫颈癌感染率(65.1%)。HPV基因型范围广泛观察到是单一感染还是多重感染。经常检测到低风险的HPV 6,11和61型。 HPV-16是普遍的高危型。发现了十四种不同的HPV-16 LCR变体。十个属于欧洲血统(在意大利受试者中检出率为78.7%,在外国出生的所有同性/双性恋男性中检出率为21.3%),两个属于亚洲血统,两个属于非洲2血统。这项研究强调了在这个意大利高危人群中,肛门和宫颈HPV感染具有巨大的基因型异质性,以及主要HPV-16的明显多态性。

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