Phenotypic and genetic diversity of the traditional Lister smallpox vaccine

Garcel A; Perino J; Crance JM; Drillien R; Garin D; Favier AL

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Phenotypic and genetic diversity of the traditional Lister smallpox vaccine

机译：传统李斯特菌天花疫苗的表型和遗传多样性

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As an initial step in the development of a second-generation smallpox vaccine derived from the Lister strain, to be prepared for a variola virus threat, diversity of the traditional vaccine was examined by characterizing a series of ten viral clones.In vitro and in vivo phenotypic studies showed that the biological behavior of the clones diverged from each other and in most cases diverged from the vaccinia virus (VACV) Lister parental population. Taken together, these results demonstrate the heterogeneity of the viral population within the smallpox vaccine and highlight the difficulty in choosing one clone which would meet the current requirements for a safe and effective vaccine candidate.

机译：作为研制针对李斯特菌的第二代天花疫苗的第一步，该疫苗旨在应对天花病毒的威胁，通过表征一系列十个病毒克隆来检验传统疫苗的多样性。表型研究表明，克隆的生物学行为彼此不同，并且在大多数情况下与痘苗病毒（VACV）Lister亲本群体不同。总而言之，这些结果证明了天花疫苗中病毒种群的异质性，并突出说明了选择一个克隆的难度，该克隆将满足当前对安全有效的候选疫苗的要求。

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《Vaccine》 |2009年第5期|共10页
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Garcel A; Perino J; Crance JM; Drillien R; Garin D; Favier AL;
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中图分类卫生标准、卫生检查、医药管理;
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1. Phenotypic and genetic diversity of the traditional Lister smallpox vaccine [J] . Garcel A, Perino J, Crance JM, Vaccine . 2009,第5期

机译：传统李斯特菌天花疫苗的表型和遗传多样性
2. Short- and long-term immunogenicity and protection induced by non-replicating smallpox vaccine candidates in mice and comparison with the traditional 1st generation vaccine. [J] . Ferrier-Rembert A, Drillien R, Tournier JN, Vaccine . 2008,第14期

机译：非复制型天花疫苗候选物在小鼠中诱导的短期和长期免疫原性和保护作用，并与传统的第一代疫苗进行比较。
3. Short communication: Phenotypic and genetic diversity of wild Lactococcus lactis isolated from traditional Pecorino cheeses of Tuscany [J] . B. Turchi, M. L. Van Tassell, A. Lee, Journal of dairy science . 2013,第6期

机译：简短交流：从托斯卡纳传统佩科里诺干酪分离的野生乳酸乳球菌的表型和遗传多样性
4. Linking Raman-Based Phenotypic Profiling and Phylogenetic Diversity to Reveal EBPR Physiological Characteristics [C] . Yueyun Li, Helen A. Cope, Mokhlesur Rahman, Annual Water Environment Federation technical exhibition and conference . 2018

机译：链接基于拉曼的表型分析和系统发育多样性，揭示EBPR生理特征
5. New Tools for Var Gene Assembly and Analysis of Genetic Diversity of var2csa, the Locus Encoding a Placental Malaria Vaccine Candidate Antigen: Vaccine Development Implications [D] . Dara, Antoine 2017

机译：var基因组装的新工具和var2csa的遗传多样性分析，编码胎盘疟疾疫苗候选抗原的基因座：疫苗开发意义
6. Genome Sequence of Vaccinia virus Strain Lister-Butantan a Lister Vaccine Variant Used during a Smallpox Eradication Campaign in Brazil [O] . Felipe Assis, Giliane Trindade, Betânia Drumond, 2016

机译：痘苗病毒株李斯特-布坦坦的基因组序列巴西天花根除运动中使用的李斯特疫苗变体
7. Postexposure Immunization with Modified Vaccinia Virus Ankara or Conventional Lister Vaccine Provides Solid Protection in a Murine Model of Human Smallpox [O] . Nir Paran, Yasemin Suezer, Shlomo Lustig, 2009

机译：用改性痘苗病毒免疫接种免疫疫苗ankara或常规李斯特疫苗提供了人类天花鼠的小鼠模型中的固体保护

Phenotypic and genetic diversity of the traditional Lister smallpox vaccine

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