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首页> 外文期刊>Vaccine >Exosomes are an effective vaccine against congenital toxoplasmosis in mice
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Exosomes are an effective vaccine against congenital toxoplasmosis in mice

机译：外泌体是一种抗小鼠先天性弓形虫病的有效疫苗

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Toxoplasmosis is a serious disease in humans and may cause abortion or congenital infection if a woman is exposed to the disease for the first time during pregnancy. Infection before pregnancy normally results in immunity protecting the foetus, suggesting that it may be possible to block vertical transmission of the parasite by appropriate vaccination before pregnancy. We found that the vaccination of CBA/J mice, before pregnancy, with exosomes secreted by SRDCs pulsed in vitro with Toxoplasma gondii-derived antigens (TAg) induced a protective response in the pups. Indeed, vaccination resulted in the presence of significantly fewer cysts in pup brains. This protection was associated with strong humoral responses in the serum in vivo. We also observed cellular responses in vivo, with cell proliferation associated with the production of cytokines by the splenocytes. Thus, exosomes are nucleic acid-free vesicles able to induce immune responses correlated with protection against T. gondii infection in a congenital model. They are therefore a potentially useful tool for vaccination against infectious disease.
机译：弓形虫病是人类的一种严重疾病，如果妇女在怀孕期间第一次接触该疾病，可能会导致流产或先天性感染。怀孕前感染通常会产生保护胎儿的免疫力，这表明在怀孕前通过适当的疫苗接种有可能阻止寄生虫的垂直传播。我们发现，在怀孕前，对CBA / J小鼠进行疫苗接种，接种由弓形虫弓形虫衍生抗原（TAg）体外脉冲产生的SRDC分泌的外泌体，可以在幼崽中产生保护性反应。确实，接种疫苗导致幼仔脑中的囊肿明显减少。这种保护与体内血清中强烈的体液反应有关。我们还观察到了体内的细胞反应，细胞增殖与脾细胞产生细胞因子有关。因此，外泌体是无核酸的囊泡，能够在先天性模型中诱导与抗弓形虫感染相关的免疫反应。因此，它们是预防传染病疫苗的潜在有用工具。

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