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首页> 外文期刊>Vaccine >Comparison of the immunogenicity and safety of measles vaccine administered alone or with live, attenuated Japanese encephalitis SA 14-14-2 vaccine in Philippine infants.
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Comparison of the immunogenicity and safety of measles vaccine administered alone or with live, attenuated Japanese encephalitis SA 14-14-2 vaccine in Philippine infants.

机译：菲律宾婴儿单独或与减毒的日本脑炎SA 14-14-2活疫苗一起接种麻疹疫苗的免疫原性和安全性比较。

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Japanese encephalitis (JE) virus is a major cause of disease, disability, and death in Asia. An effective, live, attenuated JE vaccine (LJEV) is available; however, its use in routine immunization schedules is hampered by lack of data on concomitant administration with measles vaccine (MV). This study evaluated the immunogenicity and reactogenicity of LJEV and MV when administered at the same or separate study visits in infants younger than 1 year of age. Three groups of healthy infants were randomized to receive LJEV at age of 8 months and MV at 9 months (Group 1; n=100); MV and LJEV together at 9 months (Group 2; n=236); or MV and LJEV at 9 and 10 months, respectively (Group 3; n=235). Blood was obtained 4 weeks after each vaccine administration to determine antibody levels for measles and JE. Reactogenicity was assessed by parental diaries and clinic visits. Four weeks after immunization, measles seroprotection rates (defined as >/=340mIU/ml) were high and comparable in all three groups and specifically, rates in the combined MV-LJEV (Group 2) were not statistically inferior to those in Group 3 receiving MV separately (96% versus 100%, respectively). Likewise, the LJEV seroprotection rates were high and similar between the three groups. The reactogenicity profiles of the three vaccine schedules were also analogous. LJEV and MV administered together are well tolerated and immunogenic in infants younger than 1 year. These results should facilitate incorporation of LJEV into routine immunization schedules with MV.
机译：日本脑炎（JE）病毒是亚洲疾病，致残和死亡的主要原因。有一种有效的减毒乙脑活疫苗（LJEV）。然而，由于缺乏有关与麻疹疫苗（MV）同时给药的数据，其在常规免疫方案中的使用受到阻碍。这项研究评估了LJEV和MV在1岁以下婴儿在相同或单独的研究访视中给药时的免疫原性和反应原性。将三组健康婴儿随机分为8个月大的LJEV和9个月的MV（组1; n = 100）。 MV和LJEV一起在9个月时出现（第2组; n = 236）;或分别在9和10个月时的MV和LJEV（第3组; n = 235）。每次接种疫苗4周后取血以确定麻疹和JE的抗体水平。通过父母日记和诊所就诊来评估反应原性。免疫后四周，麻疹血清保护率（定义为> / = 340mIU / ml）在所有三组中均较高且可比，具体而言，组合MV-LJEV（组2）的发生率在统计学上不低于组3接受者MV分别（分别为96％和100％）。同样，三组之间的LJEV血清保护率很高且相似。三种疫苗方案的反应原性概况也相似。 LJEV和MV一起给药对1岁以下的婴儿具有良好的耐受性和免疫原性。这些结果应有助于将LJEV纳入MV的常规免疫方案中。

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