The antigen-specific memory CD8 super(+) T-cell response induced by BCG in cattle resides in the CD8 super(+) gamma / delta TCR super(-)CD45RO super(+) T-cell population

Hogg Alison E; Worth Andrew; Beverley Peter; Howard Christopher J

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The antigen-specific memory CD8 super(+) T-cell response induced by BCG in cattle resides in the CD8 super(+) gamma / delta TCR super(-)CD45RO super(+) T-cell population

机译：BCG在牛中诱导的抗原特异性记忆CD8 super（+）T细胞应答位于CD8 super（+）γ/δTCR super（-）CD45RO super（+）T细胞群体中

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Tuberculosis (TB) remains a worldwide leading cause of death among infectious diseases. Development of safer and more efficacious vaccines requires a basic understanding of the protective mechanisms induced by BCG. Here we show that vaccination of cattle with BCG induces CD8 super(+) gamma / delta TCR super(- ) CD45RO super(+) T-cells that can produce IFN- gamma , up-regulate transcription and expression of perforin, lyse BCG-infected monocyte-derived macrophages (MoM蠁) and contribute to a reduction in the number of intracellular mycobacteria. We also observed BCG-induced CD8 super(+) responses in vivo. After infection of cattle with Mycobacterium bovis, CD8 super(+) gamma / delta TCR super(- ) CD45RO super(+) cells responded more strongly to M. bovis-infected MoM蠁 than to BCG-infected MoM蠁. These results indicate that the antigen- specific CD8 super(+) memory response resides in the CD8 super(+) gamma / delta TCR super(- ) CD45RO super(+) cell population.

机译：结核病（TB）仍然是传染病中全球主要的死亡原因。开发更安全，更有效的疫苗需要对BCG诱导的保护机制有基本的了解。在这里，我们显示牛接种BCG会诱导CD8超（+）γ/三角洲TCR超（-）CD45RO超（+）T细胞产生IFN-γ，上调穿孔素的转录和表达，裂解BCG-感染了单核细胞衍生的巨噬细胞（MoM and），并有助于减少细胞内分枝杆菌的数量。我们还观察到BCG诱导的CD8体内super（+）反应。在牛被牛分枝杆菌感染后，CD8超级（+）γ/δTCR超级（-）CD45RO超级（+）细胞对牛分枝杆菌感染的MoM +的反应比对BCG感染的MoM +的反应强。这些结果表明，抗原特异性CD8 super（+）记忆反应驻留在CD8 super（+）γ/δTCR super（-）CD45RO super（+）细胞群体中。

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《Vaccine》 |2009年第2期|共10页
作者
Hogg Alison E; Worth Andrew; Beverley Peter; Howard Christopher J;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
BCG; CD8 antigen; Immunological memory; BCG; CD8 antigen; Immunological memory; Infection; Infectious diseases; Lymphocytes T; Macrophages; Monocytes; Perforin; Transcription; Tuberculosis; Vaccines; gamma -Interferon; Mycobacterium bovis;

机译：BCG;CD8抗原;免疫记忆;BCG;CD8抗原;免疫记忆;感染;传染病;淋巴细胞T;巨噬细胞;单核细胞;穿孔素;转录;结核病;疫苗;γ-干扰素;牛分枝杆菌;

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1. The antigen-specific memory CD8 super(+) T-cell response induced by BCG in cattle resides in the CD8 super(+) gamma / delta TCR super(-)CD45RO super(+) T-cell population [J] . Hogg Alison E, Worth Andrew, Beverley Peter, Vaccine . 2009,第2期

机译：BCG在牛中诱导的抗原特异性记忆CD8 super（+）T细胞应答位于CD8 super（+）γ/δTCR super（-）CD45RO super（+）T细胞群体中
2. Minicircle DNA is superior to plasmid DNA in eliciting antigen-specific CD8 + T-cell responses [J] . DietzW.M., SkinnerN.E.B., HamiltonS.E., Molecular therapy: the journal of the American Society of Gene Therapy . 2013,第8期

机译：在引发抗原特异性CD8 + T细胞反应方面，微圆DNA优于质粒DNA
3. Functional supertype of HLA-A2 in the presentation of Flu matrix p58-66 to induce CD8+ T-cell response in a Northern Chinese population. [J] . Zhang HG, Pang XW, Shang XY, Tissue antigens. . 2003,第4期

机译：HLA-A2的功能超型在流感基质p58-66的表达中诱导中国北方人群的CD8 + T细胞反应。
4. Suppression of HIV-1 Replication by HIV-1-Irrelevant CD8~+ Cytotoxic T Lymphocytes and their Culture Supernatants [C] . M. Kubo, H. Nishitsuji, H. Liu International AIDS Conference . 2004

机译：HIV-1-Irrellate CD8〜+细胞毒性T淋巴细胞及其培养上清液抑制HIV-1复制
5. Analysis of supernumerary clonal gamma T-cell receptor gene rearrangements in cutaneous T-cell lymphoma [D] . Tolpinrud, Whitney Lynn 2011

机译：皮肤T细胞淋巴瘤中叠加克隆γT细胞受体基因重排分析
6. Minicircle DNA is Superior to Plasmid DNA in Eliciting Antigen-specific CD8+ T-cell Responses [O] . Wynette M Dietz, Nicole E B Skinner, Sara E Hamilton, 2013

机译：在消除抗原特异性CD8 + T细胞反应中小圆环DNA优于质粒DNA。
7. Identification of Salmonella typhimurium genes responsible for interference with peptide presentation on MHC class I molecules: Deltayej Salmonella mutants induce superior CD8+ T-cell responses [O] . Udi Qimron, Neta Madar, Hans-Willi Mittrucker, 2004

机译：鉴定负责干扰肽呈肽介绍的沙门氏菌毛刺基因I级分子：Deltayej Salmonella突变体诱导优异的CD8 + T细胞应答

The antigen-specific memory CD8 super(+) T-cell response induced by BCG in cattle resides in the CD8 super(+) gamma / delta TCR super(-)CD45RO super(+) T-cell population

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