Immunostimulatory effects of polar glycopeptidolipids of Mycobacteriumchelonae for inactivated rabies vaccine

Matos DCD.; Marcovistz R.; Neway T.; da Silva AMV.; Alves EN.; Pilet C.

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Immunostimulatory effects of polar glycopeptidolipids of Mycobacteriumchelonae for inactivated rabies vaccine

机译：犬分枝杆菌极性糖肽脂质对狂犬病灭活疫苗的免疫刺激作用

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Humoral and cellular immune responses were analyzed with Fuenzalida-Palacios rabies vaccine associated with pGPL-Mc, polar glycopeptidolipids extracted from Mycobacterium chelonae, aiming at its use as adjuvant. These results were compared to those obtained with BCG, a well-known immunostimulator, under the same conditions. Rabies vaccine plus pGPL-Mc (2.5 mg/ kg) induced a significant increase in serum neutralizing activity, in vitro lymphocyte proliferation (spontaneous, specific and mitogen stimulation) and delayed type hypersensibility. In addition, pGPL-Mc, as well as BCG, enhanced the Vaccine potency. Our results support further studies to encourage the use of pGPL-Mc as an immunostimulator of veterinary vaccines, before consideration for human vaccines.

机译：体液和细胞免疫应答用与pGPL-Mc相关的Fuenzalida-Palacios狂犬病疫苗进行了分析，pGPL-Mc是从chelonae分枝杆菌中提取的极性糖肽脂质，旨在用作佐剂。将这些结果与在相同条件下用著名的免疫刺激剂BCG获得的结果进行比较。狂犬病疫苗加pGPL-Mc（2.5 mg / kg）引起血清中和活性，体外淋巴细胞增殖（自发，特异性和促有丝分裂原刺激）和迟发型高敏性显着增加。另外，pGPL-Mc和BCG增强了疫苗效力。我们的结果支持进一步的研究，以鼓励在考虑使用人类疫苗之前鼓励使用pGPL-Mc作为兽用疫苗的免疫刺激剂。

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《Vaccine》 |2000年第20期|共7页
作者
Matos DCD.; Marcovistz R.; Neway T.; da Silva AMV.; Alves EN.; Pilet C.;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Rabies vaccine; Adjuvants; Immune responses; Pgpl-mc; Calmette-guerin; Mice; Interferon; Infection; Interleukin-2; Protection; Resistance; Modulation; Responses;

机译：狂犬病疫苗;佐剂;免疫应答;Pgpl-mc;卡尔梅特-游林;小鼠;干扰素;感染;白细胞介素-2;保护;抵抗力;调节;反应;

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1. Immunostimulatory effects of polar glycopeptidolipids of Mycobacteriumchelonae for inactivated rabies vaccine [J] . Matos DCD., Marcovistz R., Neway T., Vaccine . 2000,第20期

机译：犬分枝杆菌极性糖肽脂质对狂犬病灭活疫苗的免疫刺激作用
2. Dietary L-proline supplementation confers immunostimulatory effects on inactivated Pasteurella multocida vaccine immunized mice [J] . Wenkai Ren, Lingxiu Zou, Zheng Ruan Amino acids . 2013,第3期

机译：膳食L-脯氨酸补充剂对灭活的多杀巴斯德氏菌疫苗免疫小鼠具有免疫刺激作用
3. Inactivated Rabies Virus-Based Ebola Vaccine Preserved by Vaporization Is Heat-Stable and Immunogenic Against Ebola and Protects Against Rabies Challenge [J] . Kurup Drishya, Fisher Christine R., Smith Todd G., The Journal of Infectious Diseases . 2019,第9期

机译：通过汽化保存的灭活狂犬病病毒的埃博拉疫苗是对埃博拉的热稳定和免疫原性，并防止狂犬病攻击
4. Efficacy and Duration of Immunity of an Inactivated Equine Rabies Virus Vaccine [C] . D. Craig Barnett, Mark W. Mellencamp, Nallakannu Lakshmanan, Annual Convention of the American Association of Equine Practitioners . 2009

机译：灭活马狂犬病病毒疫苗免疫的疗效和持续时间
5. Rabies virus-based HIV-1 vaccine vector: impact of antigen presenting cells and immunostimulatory molecules. [D] . Wanjalla, Celestine N. 2013

机译：基于狂犬病病毒的HIV-1疫苗载体：抗原呈递细胞和免疫刺激分子的影响。
6. Inactivated Rabies Virus-Vectored Immunocontraceptive Vaccine in a Thermo-Responsive Hydrogel Induces High and Persistent Antibodies against Rabies but Insufficient Antibodies against Gonadotropin-Releasing Hormone for Contraception [O] . Xianfu Wu, Yong Yang, Chantal Kling, 2019

机译：在热响应水凝胶中灭活的狂犬病病毒载体免疫避孕疫苗诱导了针对狂犬病的高强度和持久性抗体但针对促性腺激素释放激素的避孕抗体不足
7. Rise and Fall of Neutralizing Antibody Titer in Goats Injected with Living Rabies Vaccine (Flury Strain) and Inactivated Rabies Vaccine (Ultraviolet Ray Inactivated) [O] . Y. KIKUCHI, H. IWABUCHI, N. IMANISHI, 1964

机译：山羊注射患有活狂犬病疫苗（浓度菌株）和灭活狂犬病疫苗（紫外线灭活）中和抗体滴度的上升和下降

Immunostimulatory effects of polar glycopeptidolipids of Mycobacteriumchelonae for inactivated rabies vaccine

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