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首页> 外文期刊>Vaccine >Immunogenicity and reactogenicity of the Biken acellular pertussis vaccinein young adults
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Immunogenicity and reactogenicity of the Biken acellular pertussis vaccinein young adults

机译：比肯脱细胞百日咳疫苗在年轻人中的免疫原性和反应原性

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摘要

To assess the reactogenicity and immunogenicity of the Biken acellular pertussis vaccine (Pa) following administration of a single vaccine dose to young adults with or without a history of prior pertussis immunization, 104 healthy, male and female adults without primary pertussis immunization were enrolled in Mainz (former West Germany; "not previously pertussis vaccinated", N-PPV-group); in parallel, 103 adults with a history of having received greater than or equal to four doses of a combined diphtheria-, tetanus-toroid, whole-cell pertussis Vaccine (DTwP) were enrolled in Magdeburg (former East Germany; "previously pertussis-vaccinated", PPV-group). Large areas of redness (> 20 mm) were seen in 2.9%/1.0% of subjects in the N-PPV/PPV group, and a large swelling was seen in 6.8%/1.0%, respectively. As compared to baseline concentrations, antibody titers to PT and FHA were 77-(PT)/64-(FHA) (N-PPV group) and 94-(PT)/126-(FHA) fold (PPV group) higher. The study vaccine was safe and induced infrequent and mostly mild, local and general symptoms that all resolved spontaneously; it was highly immunogenic in adults, whether or not they had been previously vaccinated with DTwP.
机译：为了评估对有或没有既往百日咳疫苗免疫史的年轻人单次注射疫苗后，倍肯脱细胞百日咳百日咳疫苗（Pan）的反应原性和免疫原性，在Mainz纳入了104名未进行初次百日咳疫苗免疫的健康，男性和女性成年人（前西德;“以前未接种百日咳疫苗”，N-PPV-组）;同时，在马格德堡（前东德;曾接受过百日咳疫苗接种）入选了103名成年史，他们接受过大于或等于四剂白喉，破伤风-环状，全细胞百日咳组合疫苗（DTwP）的历史“，PPV组）。在N-PPV / PPV组中，有2.9％/ 1.0％的受试者出现大范围的发红（> 20毫米），并且在6.8％/ 1.0％的受试者中出现了较大的肿胀。与基线浓度相比，针对PT和FHA的抗体效价分别高77-（PT）/ 64-（FHA）（N-PPV组）和94-（PT）/ 126-（FHA）倍（PPV组）。该研究疫苗是安全的，很少引起，主要是轻度，局部和一般症状，均能自发缓解;它对成年人具有高度的免疫原性，无论他们之前是否曾接受过DTwP疫苗接种。

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