Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response

Lustig S; Maik-Rachline G; Paran N; Melamed S; Israely T; Erez N; Orr N; Reuveny S; Ordentlich A; Laub O; Shafferman A; Velan B

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Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response

机译：有效的暴露后预防针对牛痘免疫球蛋白的致死性正痘病毒感染涉及诱导适应性免疫反应

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The therapeutic potential of human vaccinia immunoglobulin (VIG) in orthopoxvirus infection was examined using two mouse models for human poxvirus, based on Ectromelia virus and Vaccinia Western Reserve (WR) respiratory infections. Despite the relatively fast clearance of human VIG from mice circulation, a single VIG injection protected immune-competent mice against both infections. Full protection against lethal Ectromelia virus infection was achieved by VIG injection up to one day post-exposure, and even injection of VIG two or three days post-infection conferred solid protection (60-80%). Nevertheless, VIG failed to protect VACV-WR challenged immune-deficient mice, even though repeated injections prolonged SCID mice survival. These results suggest the involvement of host immunity in protection. VIG provides the initial protective time-window allowing induction of the adaptive response required to achieve complete protection. Additionally, VIG can be administered in conjunction with active Vaccinia-Lister vaccination. Vaccine efficiency is not impaired, providing a non-prohibitive VIG dose is used. Thus, VIG can be used as a prophylactic measure against post-vaccinal complications but could also serve for post-exposure treatment against smallpox.

机译：使用两种人痘病毒小鼠模型检查了牛痘免疫球蛋白（VIG）在正痘病毒感染中的治疗潜力，这两种小鼠模型均基于Ectromelia病毒和Vaccinia Western Reserve（WR）呼吸道感染。尽管从小鼠循环中清除人VIG的速度相对较快，但是一次VIG注射可以保护具有免疫能力的小鼠免受两种感染的侵害。通过在暴露后1天之内注射VIG，可以实现针对致命性埃斯特罗里亚病毒感染的全面保护，甚至在感染后2或3天甚至注射VIG也可提供固体保护（60-80％）。尽管如此，VIG未能保护VACV-WR攻击的免疫缺陷小鼠，即使反复注射可延长SCID小鼠的存活时间。这些结果表明宿主免疫力参与保护。 VIG提供了初始保护时间窗口，可以感应出实现完全保护所需的自适应响应。另外，VIG可以与主动Vaccinia-Lister疫苗联合使用。只要使用非禁止的VIG剂量，疫苗的使用效率就不会受到损害。因此，VIG可用作预防疫苗后并发症的预防措施，但也可用于暴露后针对天花的治疗。

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《Vaccine》 |2009年第11期|共9页
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Lustig S; Maik-Rachline G; Paran N; Melamed S; Israely T; Erez N; Orr N; Reuveny S; Ordentlich A; Laub O; Shafferman A; Velan B;
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中图分类卫生标准、卫生检查、医药管理;
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1. Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response [J] . Lustig S, Maik-Rachline G, Paran N, Vaccine . 2009,第11期

机译：有效的暴露后预防针对牛痘免疫球蛋白的致死性正痘病毒感染涉及诱导适应性免疫反应
2. IFN mimetic as a therapeutic for lethal vaccinia virus infection: possible effects on innate and adaptive immune responses. [J] . Ahmed CM, Martin JP, Johnson HM The Journal of Immunology: Official Journal of the American Association of Immunologists . 2007,第7期

机译：干扰素模拟物可作为致命的痘苗病毒感染的治疗剂：对先天性和适应性免疫反应的可能影响。
3. Salmonella Typhimurium, the major causative agent of foodborne illness inactivated by a phage lysis system provides effective protection against lethal challenge by induction of robust cell-mediated immune responses and activation of dendritic cells [J] . Gayeon Won, John Hwa Lee Veterinary research . 2017,第1期

机译：鼠伤寒沙门氏菌是通过噬菌体裂解系统失活的食源性疾病的主要病原体，可通过诱导强大的细胞介导的免疫反应和激活树突状细胞来提供有效的防御致命性攻击的保护
4. MULTI-TASKING AN INACTIVATED INFLUENZA VACCINE TO PROVIDE RAPID INNATE IMMUNE SYSTEM-MEDIATED AND SUBSEQUENT LONG-TERM ADAPTIVE IMMUNITY AGAINST INFLUENZA AND SECONDARY PNEUMOCOCCAL INFECTIONS [C] . Brendon Y Chua, Chinn Yi Wong, Edin J Mifsud, Vaccine technology VI . 2016

机译：多次服用灭活的流感疫苗，以提供快速的天然免疫系统介导的和随后的长期适应性免疫力，以应对流感和第二次肺炎球菌感染
5. Involvement of chicken melanoma differentiation-associated gene 5 in innate and adaptive immune response to infectious bursal disease virus infection. [D] . Lee, Chih-Chun. 2013

机译：鸡黑素瘤分化相关基因5参与对传染性法氏囊病病毒感染的先天性和适应性免疫反应。
6. Salmonella Typhimurium the major causative agent of foodborne illness inactivated by a phage lysis system provides effective protection against lethal challenge by induction of robust cell-mediated immune responses and activation of dendritic cells [O] . Gayeon Won, John Hwa Lee 2017

机译：鼠伤寒沙门氏菌是通过噬菌体裂解系统失活的食源性疾病的主要病原体可通过诱导强大的细胞介导的免疫反应和激活树突状细胞来提供有效的防御致命性攻击的保护
7. IFN Mimetic as a Therapeutic for Lethal Vaccinia Virus Infection: Possible Effects on Innate and Adaptive Immune Responses [O] . Chulbul M. Ahmed, James P. Martin, Howard M. Johnson 2007

机译：IFN模仿作为致命痘苗病毒感染的治疗方法：对先天和适应性免疫应答的可能影响

Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response

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