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Comparative analysis of Salmonella enterica serovar Enteritidis mutants with a vaccine potential

机译：具有疫苗潜力的肠炎沙门氏菌血清肠炎沙门氏菌突变体的比较分析

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If any new live Salmonella vaccine is introduced in the future, it is quite probable that detailed characterisation of its attenuation will be required. In this study we therefore compared 34 isogenic mutants of S. Enteritidis in aroA, aroD, galE, ssrA, sseA, phoP, rpoS, ompR, htrA, clpP, lon, rfaL, rfaG, rfaC, hfq, sodCI, hilA, sipA, avrA, sopB, sopA, sopE, sifA, shdA, fliC, fur, relA, spoT, rel- spoT, misL, rmbA, STM4258, STM4259 and spvBC genes for their resistance to stresses likely to be expected in the host and for their virulence and immunogenicity in Balb/C mice. We found that the cold and bile resistances essentially did not correlate with the resistances to other stress factors. Resistance to acid pH, heat, polymyxin and serum correlated with each other and also with the attenuation. When the residual virulence and immunogenicity were both considered, mutants in htrA, ompR, aroA, aroD and lon performed the best in mice. Furthermore, when a detailed comparison of polymyxin and serum sensitive mutants was performed, the serum sensitive mutants were more immunogenic.
机译：如果将来引入任何新的沙门氏菌活疫苗，很有可能需要详细描述其减毒作用。因此，在这项研究中，我们比较了a.AroA，aroD，galE，ssrA，sseA，phoP，rpoS，ompR，htrA，clpP，lon，rfaL，rfaG，rfaC，hfq，sodCI，hilA，sipA， avrA，sopB，sopA，sopE，sifA，sdA，fliC，fur，relA，spoT，relspoT，misL，rmbA，STM4258，STM4259和spvBC基因对宿主可能产生的应激抗性及其毒性和Balb / C小鼠的免疫原性。我们发现，抗寒性和胆汁性与抗其他压力因素基本不相关。对酸性pH，热，多粘菌素和血清的抗性相互关联，也与衰减相关。当同时考虑残留毒力和免疫原性时，htrA，ompR，aroA，aroD和lon中的突变株在小鼠中表现最佳。此外，当对多粘菌素和血清敏感突变体进行详细比较时，血清敏感突变体具有更高的免疫原性。

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