The expanding vaccine development pipeline, 1995-2008.

Davis M. M.; Butchart A. T.; Coleman M. S.; Singer D. C.; Wheeler J. R. C.; Pok A.; Freed G. L.

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The expanding vaccine development pipeline, 1995-2008.

机译：1995-2008年，不断扩大的疫苗开发渠道。

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Successful launches of recently licensed vaccines contrast with pharmaceutical industry concerns about unfavorable market conditions, making the status and future of vaccine development uncertain. We assessed trends in private-sector vaccine research and development for the period 1995-2008, using a global pharmaceutical database to identify prophylactic vaccines in preclinical, Phase I, Phase II, or Phase III stages of development. We counted companies that research and/or manufacture vaccines ("vaccine originators") and their vaccine products in each year. The global number of vaccine originators doubled (to 136), as did the number of prophylactic vaccine products in development (to 354); the majority of this growth was in preclinical and early phase clinical research. Because rapid growth in earlier research phases has not yet led to growth in Phase III, it is not yet clear whether recent industry expansion will translate to an increase in the number of available vaccines in the near future.

机译：最近获得许可的疫苗的成功推出与制药行业对不利的市场条件的担忧形成鲜明对比，这使得疫苗开发的状况和未来不确定。我们使用全球药品数据库来识别处于临床前，I期，II期或III期开发阶段的预防性疫苗，从而评估了1995-2008年期间私营部门疫苗研发的趋势。我们统计了每年研究和/或生产疫苗（“疫苗始发者”）及其疫苗产品的公司。全球疫苗始发者数量翻了一番（达到136个），正在开发的预防性疫苗产品数量也达到了354个;这种增长的大部分是在临床前和早期临床研究中。由于早期研究阶段的快速增长尚未导致第三阶段的增长，因此目前尚不清楚最近的行业扩张是否会在不久的将来转化为可用疫苗数量的增加。

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《Vaccine》 |2010年第5期|共4页
作者
Davis M. M.; Butchart A. T.; Coleman M. S.; Singer D. C.; Wheeler J. R. C.; Pok A.; Freed G. L.;
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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
product development; research; vaccine development; vaccines;

机译：产品开发;研究;疫苗开发;疫苗;

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1. The expanding vaccine development pipeline, 1995-2008. [J] . Davis M. M., Butchart A. T., Coleman M. S., Vaccine . 2010,第5期

机译：1995-2008年，不断扩大的疫苗开发渠道。
2. The 2016 Vaccine Development Pipeline: A special issue from the World Health Organization Product Development for Vaccine Advisory Committee (PDVAC) Preface [J] . Giersing Birgitte K., Modjarrad Kayvon, Kaslow David C., Vaccine . 2016,第26期

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3. Defining the objectives of the AIDS vaccine for Asia network: report of the WHO-UNAIDS/Global HIV vaccine enterprise regional consultation on expanding AIDS vaccine research and development capacity in Asia. [J] . Rerks Ngarm S, Pitisuttithum P, Ganguly N, Current opinion in HIV and AIDS . 2010,第5期

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7. The 2016 Vaccine Development Pipeline: A special issue from the World Health Organization Product Development for Vaccine Advisory Committee (PDVAC) [O] . Giersing Birgitte K., Modjarrad Kayvon, Kaslow David C., 2016

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The expanding vaccine development pipeline, 1995-2008.

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