...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >A novel adjuvant for vaccine development in the aged.
【24h】

A novel adjuvant for vaccine development in the aged.

机译：用于老年人疫苗开发的新型佐剂。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A conformationally-biased, response-selective agonist of human C5a65-74 (EP67) activated antigen presenting cells (APC) from aged C57Bl/6 mice in vitro and the generation of antigen (Ag)-specific antibody (Ab) responses in aged mice in vivo. EP67, induced the release of the pro-inflammatory cytokines IL-6, TNF alpha , and INF gamma from splenic APCs obtained from both aged and young mice. Both aged and young mice produced high Ag-specific IgG Ab titers when immunized with EP67-containing vaccines to ovalbumin (OVA-EP67) and to a protein (rPrp1) from the cell wall of Coccidioides (rPrp1-EP67). Immunization with EP67-containing vaccines resulted in higher IgG titers in both young and aged mice compared to mice immunized with OVA adsorbed to alum (OVA/alum) and Prp1 admixed with CpG (rPrp1 +CpG). Aged and young mice immunized with the EP67-containing vaccines generated higher titers of IgG1 and IgG2b relative to their aged-matched counterparts immunized with OVA/alum or Prp1 +CpG. These results indicate that EP67 induces humoral immunity in aged mice not obtainable with alum and CpG. These results support the use of EP67 as a potential vaccine adjuvant suited to the elderly.
机译：体外老化的C57Bl / 6小鼠C5a 65-74 （EP67）活化抗原呈递细胞（APC）的构象偏向，响应选择性激动剂（i）体内衰老小鼠的抗原（Ag）特异性抗体（Ab）反应的检测。 EP67诱导了从老年和幼年小鼠脾脏APC中释放促炎性细胞因子IL-6，TNFα和INFγ。用含EP67的卵白蛋白（OVA-EP67）疫苗和 Coccidioides （rPrp1- EP67）。与用明矾吸附的OVA（OVA /明矾）和掺有CpG的Prp1（rPrp1 + CpG）免疫的小鼠相比，用含EP67的疫苗免疫可在年轻和老年小鼠中产生更高的IgG滴度。相对于用OVA /清液或Prp1 + CpG免疫的老年配对小鼠，用含EP67疫苗免疫的老年小鼠产生更高的IgG1和IgG2b效价。这些结果表明，EP67可在明矾和CpG无法获得的老年小鼠中诱导体液免疫。这些结果支持使用EP67作为适合老年人的潜在疫苗佐剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号