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首页> 外文期刊>Vaccine >Evaluation of the efficacy and safety of the Rift Valley Fever Clone 13 vaccine in sheep.
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Evaluation of the efficacy and safety of the Rift Valley Fever Clone 13 vaccine in sheep.

机译：评价裂谷热克隆13疫苗在绵羊中的功效和安全性。

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The efficacy and safety of the naturally attenuated Rift Valley Fever (RVF) Clone 13 vaccine were evaluated in ovines in three different experiments involving 38 ewes at different stages of pregnancy, their offsprings and four rams. In Experiment 1, 4 rams and a total of 13 pregnant ewes were vaccinated and monitored during vaccination and after a challenge with a virulent RVF virus. The ewes were vaccinated at either 50 or 100 days of pregnancy and some were challenged after lambing. In Experiment 2, nine oestrus-synchronized ewes were vaccinated at 50 days of pregnancy and challenged at 100 days of pregnancy together with 5 unvaccinated ewes at the same stage of pregnancy. In Experiment 3, 16 oestrus-synchronized ewes were vaccinated with 3 different doses of the RVF Clone 13 vaccine and challenged together with unvaccinated pregnant ewes at either 30 or 50 days of pregnancy. The results from the three experiments indicated that the vaccine did not induce clinical manifestation of RVF such as abortion in pregnant ewes, teratogeny in their offsprings, or pyrexia in all vaccinated animals. Vaccination with RVF Clone 13 vaccine also prevented clinical RVF following virulent challenge at different stages of pregnancy while unvaccinated control ewes showed pyrexia, aborted or died of RVF. A vaccine dose-response effect was also observed.
机译：在三个不同的实验中，在绵羊中评估了天然减毒裂谷热（RVF）克隆13疫苗的功效和安全性，涉及38个母羊在怀孕的不同阶段，它们的后代和四个公羊。在实验1中，在疫苗接种过程中以及用强力RVF病毒攻击后，对4只公羊和总共13只母羊进行了疫苗接种和监测。母羊在怀孕50天或100天时接种疫苗，有些母羊在产羔后接受攻击。在实验2中，在怀孕50天时接种了9株发情同步的母羊，在怀孕100天时激发了5只未接种的母羊，并在怀孕的同一阶段对其进行了攻击。在实验3中，用3种不同剂量的RVF Clone 13疫苗接种了16个发情期同步化的母羊，并在怀孕30天或50天与未接种的母羊一起攻击。这三个实验的结果表明，该疫苗不会诱导RVF的临床表现，例如怀孕母羊的流产，其后代的致畸性或所有疫苗接种动物的发热。 RVF疫苗的接种在怀孕的不同阶段进行强毒攻击后，克隆13疫苗也可以预防临床RVF，而未接种疫苗的母羊则表现出发热，流产或死于RVF。还观察到疫苗剂量反应作用。

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