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首页> 外文期刊>Vaccine >Role of T cell competition in the induction of cytotoxic T lymphocyte activity during viral vector-based immunization regimens.
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Role of T cell competition in the induction of cytotoxic T lymphocyte activity during viral vector-based immunization regimens.

机译：在基于病毒载体的免疫方案中，T细胞竞争在诱导细胞毒性T淋巴细胞活性中的作用。

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摘要

T cell competition between antigen- and vector-specific T cells may determine the outcome of viral vector-based immunization regimens, as we previously proposed. Here, we unravelled the interplay between antigen- and vector-specific immunity, using recombinant Semliki Forest virus (rSFV). Priming of mice with rSFV, encoding LacZ (SFVLacZ), or with empty rSFV strongly suppressed subsequent induction of ovalbumin or Human Papilloma virus (HPV) E6/E7-specific CTL activity by a booster with SFVeOVA or SFVeE6,7, respectively. Yet, priming with irradiated, i.e. replication-defective, SFVLacZ did not affect subsequent CTL induction, indicating that the interfering vector-specific immunity was directed against the viral replicase. However, immune responses against the strongly immunogenic nucleoprotein of influenza virus encoded by SFV were less severely affected by priming with SFVLacZ. Thus the outcome of heterologous prime-boost immunizations appears to depend on the immunogenicity of the respective antigens.
机译：正如我们先前所提出的，抗原特异性和载体特异性T细胞之间的T细胞竞争可能决定基于病毒载体的免疫方案的结果。在这里，我们使用重组的塞姆利基森林病毒（rSFV）揭示了抗原和载体特异性免疫之间的相互作用。用分别编码SFVeOVA或SFVeE6,7的增强剂对编码LacZ（SFVLacZ）的rSFV或空rSFV的小鼠进行的启动作用强烈抑制了卵白蛋白或人乳头瘤病毒（HPV）E6 / E7特异性CTL活性的后续诱导。然而，用辐照的SFVLacZ（即复制缺陷的）引发并不会影响随后的CTL诱导，表明干扰的载体特异性免疫是针对病毒复制酶的。但是，对SFV编码的流感病毒的强免疫原性核蛋白的免疫反应受SFVLacZ引发的影响较小。因此，异源初免-加强免疫的结果似乎取决于相应抗原的免疫原性。

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