The global introduction of inactivated polio vaccine can circumvent the oral polio vaccine paradox

Heinsbroek Ellen; Ruitenberg E. Joost

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The global introduction of inactivated polio vaccine can circumvent the oral polio vaccine paradox

机译：灭活脊髓灰质炎疫苗的全球引进可以规避口服脊髓灰质炎疫苗的悖论

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This literature review identifies the factors that influence the decision to introduce inactivated polio vaccine (IPV) in developing countries as opposed to the policy of vaccine cessation. Attenuated viruses in the oral polio vaccine (OPV) can replicate, revert to neurovirulence and become transmissible circulating vaccine-derived polioviruses (cVDPVs), preventing use of the vaccine in the post-eradication era. This literature review identifies (1) risks of complete cessation of vaccination, (2) barriers and (3) solutions for the introduction of IPV in developing countries. The reviewed literature favours to circumvent the so-called "OPV paradox" by global introduction of IPV.

机译：这篇文献综述指出了与停用疫苗政策相反，影响在发展中国家引入灭活脊髓灰质炎疫苗（IPV）的决定的因素。口服脊髓灰质炎疫苗（OPV）中的减毒病毒可以复制，恢复为神经毒力，并成为可传播的循环疫苗衍生脊髓灰质炎病毒（cVDPVs），从而在根除后时代阻止了疫苗的使用。这篇文献综述确定了（1）完全停止接种疫苗的风险，（2）障碍和（3）在发展中国家引入IPV的解决方案。综述文献倾向于通过在全球范围内引入IPV来规避所谓的“ OPV悖论”。

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《Vaccine》 |2010年第22期|共6页
作者
Heinsbroek Ellen; Ruitenberg E. Joost;
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正文语种 eng
中图分类医学免疫学;
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Pharmacology; Infection; Epidemiology: Population Studies; Neurology: Human Medicine; Medical Sciences;

机译：药理学;感染;流行病学：人口研究;神经病学：人类医学;医学;

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专利

1. The global introduction of inactivated polio vaccine can circumvent the oral polio vaccine paradox [J] . Heinsbroek Ellen, Ruitenberg E. Joost Vaccine . 2010,第22期

机译：灭活脊髓灰质炎疫苗的全球引进可以规避口服脊髓灰质炎疫苗的悖论
2. Intestinal Immunity to Poliovirus Following Sequential Trivalent Inactivated Polio Vaccine/Bivalent Oral Polio Vaccine and Trivalent Inactivated Polio Vaccine-only Immunization Schedules: Analysis of an Open-label, Randomized, Controlled Trial in Chilean Infants [J] . Brickley Elizabeth B., Wieland-Alter Wendy, Connor Ruth I, Clinical infectious diseases . 2018,第Suppla1期

机译：脊髓病毒后肠道免疫术后脊髓灰质炎病毒疫苗/二价口服脊髓灰质炎疫苗和三价灭活脊髓灰质炎疫苗免疫时间表：分析智利婴儿的开放标签，随机对照试验
3. Experience With Inactivated Polio Vaccine Introduction and the "Switch" From Trivalent to Bivalent Oral Polio Vaccine in the World Health Organization's Western Pacific Region [J] . Gurung Santosh, Harris Jennifer B., Eltayeb Abu Obeida, The Journal of Infectious Diseases . 2017,第Suppla1期

机译：在世界卫生组织西太平洋地区的三价口腔脊髓灰质炎疫苗的三价口交疫苗的灭活脊髓灰质炎疫苗介绍和“开关”的经验
4. Single Injection Delivery System for Sabin Inactivated Polio Vaccine [C] . Xueguang Lu, Kevin J. McHugh, Zachary Tochka, Society for Biomaterials annual meeting and exposition . 2019

机译：萨宾灭活脊髓灰质炎疫苗单次注射输送系统
5. Compliance of Caregivers with Polio Vaccine Dosages and Timelines in Lagos State, Nigeria [D] . Salako Smith, Grace. 2017

机译：尼日利亚拉各斯州看护者对脊髓灰质炎疫苗剂量和时间表的遵守情况
6. Introduction of Inactivated Poliovirus Vaccine and Trivalent Oral Polio Vaccine/Bivalent Oral Polio Vaccine Switch in the African Region [O] . Carol Tevi-Benissan, Joseph Okeibunor, Gaël Maufras du Châtellier, -1

机译：在非洲地区引进灭活脊髓灰质炎疫苗和三价口服脊髓灰质炎疫苗/二价口服脊髓灰质炎疫苗开关
7. Introduction of Inactivated Poliovirus Vaccine and Trivalent Oral Polio Vaccine/Bivalent Oral Polio Vaccine Switch in the African Region [O] . Carol Tevi-Benissan, Joseph Okeibunor, Gaël Maufras du Châtellier, 2017

机译：灭活脊髓灰质炎疫苗和三价口腔脊髓灰质炎疫苗/二价口服脊髓灰质炎疫苗开关的引入

The global introduction of inactivated polio vaccine can circumvent the oral polio vaccine paradox

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