Long-term protection of mice against Leishmania major with a synthetic peptide vaccine

Spitzer N; Jardim A; Lippert D; Olafson RW

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Long-term protection of mice against Leishmania major with a synthetic peptide vaccine

机译：合成肽疫苗可长期保护小鼠免于重度利什曼原虫病

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A single synthetic T cell epitope (PT3), obtained from the histidine zinc-binding region of the metalloprotease gp63, was used in a vaccine trial using 2 virulent strains of Leishmania major (LV39 MRHP/SU/59 Neals strain and WHOM/IR/-/173). When a single subcutaneous injection of PT3 was delivered with the Th1 stimulating adjuvant poloxamer 407, BALB/c mice were protected for at least 10 months against the disease. Vaccinated mice were largely free of lesions on termination of the experiment. Protection was similar for both strains, which manifest different disease sequelae.

机译：从金属蛋白酶gp63的组氨酸锌结合区获得的单个合成T细胞表位（PT3），已在一项疫苗试验中使用，使用了2株大利什曼原虫的强毒株（LV39 MRHP / SU / 59 Neals株和WHOM / IR / -/ 173）。当用刺激Th1的佐剂泊洛沙姆407一次皮下注射PT3时，BALB / c小鼠至少可以抵抗该疾病10个月。接种的小鼠在实验终止时基本上没有损伤。两种菌株的保护作用相似，表现出不同的疾病后遗症。

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来源
《Vaccine》 |1999年第12期|共3页
作者
Spitzer N; Jardim A; Lippert D; Olafson RW;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
immunization; synthetic vaccines; synthetic peptides; metalloproteinases; vaccines; laboratory animals; experimental infections; parasites; Leishmania major; mice; protozoa;

机译：免疫;合成疫苗;合成肽;金属蛋白酶;疫苗;实验动物;实验性感染;寄生虫;大利什曼原虫;小鼠;原生动物;

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专利

1. Long-term protection of mice against Leishmania major with a synthetic peptide vaccine [J] . Spitzer N, Jardim A, Lippert D, Vaccine . 1999,第11a12期

机译：合成肽疫苗可长期保护小鼠免于重度利什曼原虫病
2. A Listeria monocytogenes-Based Vaccine That Secretes Sand Fly Salivary Protein LJM11 Confers Long-Term Protection against Vector-Transmitted Leishmania major [J] . Delbert S. Abi Abdallah, Alan Pavinski Bitar, Fabiano Oliveira, Infection and immunity . 2014,第7期

机译：分泌沙蝇唾液蛋白LJM11的基于单核细胞增生李斯特氏菌的疫苗可长期预防转染大载体的利什曼原虫
3. A new multi-epitope peptide vaccine induces immune responses and protection against Leishmania infantum in BALB/c mice [J] . Vakili Bahareh, Nezafat Navid, Zare Bijan, Medical Microbiology and Immunology . 2020,第1期

机译：一种新的多表位肽疫苗诱导Balb / C小鼠Leishmania Infantum的免疫应答和保护
4. A Synthetic 83 Amino Acid Long Peptide Corresponding to the Minimal Metacaspase Catalytic Domain Induces Cell Beath in Leishmania major [C] . Servis Catherine, Zalila Habib, Gonzalez Iveth American Peptide Symposium . 2011

机译：合成的83氨基酸长肽对应于最小的Metacaspase催化结构域诱导LeishMania主要的细胞烧音
5. Evaluation of protection induced by DNA vaccine candidate against Leishmania mexicana in BALB/c mice model. [D] . Rodarte, Rosina. 2012

机译：在BALB / c小鼠模型中评估DNA候选疫苗诱导的针对墨西哥利什曼原虫的保护作用。
6. Coadministration of the Three Antigenic Leishmania infantum Poly (A) Binding Proteins as a DNA Vaccine Induces Protection against Leishmania major Infection in BALB/c Mice [O] . Manuel Soto, Laura Corvo, Esther Garde, 2015

机译：三种抗原性婴儿利什曼原虫Poly（A）结合蛋白作为DNA疫苗的共同给药可诱导针对BALB / c小鼠的利什曼原虫主要感染的保护
7. Coadministration of the Three Antigenic Leishmania infantum Poly (A) Binding Proteins as a DNA Vaccine Induces Protection against Leishmania major Infection in BALB/c Mice [O] . Soto, Manuel, Corvo, Laura, Garde, Esther, 2015

机译：三种抗原性婴儿利什曼原虫Poly（A）结合蛋白作为DNA疫苗的共同给药可诱导针对BALB / c小鼠的利什曼原虫主要感染的保护

Long-term protection of mice against Leishmania major with a synthetic peptide vaccine

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