...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >Expression of interleukin-2 (IL-2) receptor alpha and CD45RO antigen onT-lymphocytes cultured with measles virus antigens, compared with humoralimmunity in measles vaccinees
【24h】

Expression of interleukin-2 (IL-2) receptor alpha and CD45RO antigen onT-lymphocytes cultured with measles virus antigens, compared with humoralimmunity in measles vaccinees

机译：与麻疹疫苗中的体液免疫相比，白细胞介素2（IL-2）受体α和CD45RO抗原在麻疹病毒抗原培养的T淋巴细胞上的表达

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In response to two types of measles virus (MV) antigens, a vaccine strain CAM and a wild strain isolated in 1994, the expression of IL-2 receptor alpha (CD25)(+)CD45RO(+)CD4(+) T-lymphocytes (T-cell activation) was analyzed by flow cytometry. In 75 healthy subjects with measles hemagglutination inhibition tests greater than or equal to 1:16, the percentage of T-cell activation was significantly increased compared with that in seronegative individuals (p < 0.05). Moreover, the T-cell expression was not significantly different among the vaccinated (n = 38), the naturally infected (n = 28) and the subclinically infected (exposed with wild type without history of measles infection and HI titers greater than or equal to 1:16) (n = 10) groups. T-cell activation stimulated with MV antigens and HI antibody titers persisted for almost 30 years in the vaccinated group. These results suggest that cell-mediated immunity persists for long periods after vaccination and does not be influenced by antigenic drift. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 18]
机译：针对两种类型的麻疹病毒（MV）抗原，即疫苗株CAM和1994年分离的野生株，IL-2受体α（CD25）（+）CD45RO（+）CD4（+）T淋巴细胞的表达通过流式细胞术分析（T细胞活化）。在75例麻疹血凝抑制试验大于或等于1:16的健康受试者中，与血清阴性个体相比，T细胞活化百分比显着增加（p <0.05）。此外，在接种疫苗（n = 38），自然感染（n = 28）和亚临床感染（暴露于无麻疹感染史且HI滴度大于等于）的野生型中，T细胞表达无显着差异。 1:16）（n = 10）组。接种疫苗组中，用MV抗原和HI抗体滴度刺激的T细胞活化持续了将近30年。这些结果表明，细胞介导的免疫力在疫苗接种后会持续很长时间，并且不受抗原漂移的影响。 （C）1999 Elsevier ScienceLtd。保留所有权利。 [参考：18]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号