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首页> 外文期刊>Vaccine >Serum bactericidal antibody response to serogroup C polysaccharide meningococcal vaccination in children with primary antibody deficiencies
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Serum bactericidal antibody response to serogroup C polysaccharide meningococcal vaccination in children with primary antibody deficiencies

机译：一级抗体缺乏症患儿血清C型多糖脑膜炎球菌疫苗接种对血清杀菌抗体的反应

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Primary antibody deficiencies are characterized by decreased serum levels of immunoglobulin isotypes and increased susceptibility to infection by various microorganisms including encapsulated bacteria. This study was performed in order to evaluate bactericidal antibody response of these patients to polysaccharide meningococcal vaccine. Twenty-four antibody deficient children of mean age 11.2+/-3.5 years, and 15 sex and age-matched healthy volunteers were enrolled. All subjects received meningococcal polysaccharide vaccine A+C; blood samples were collected before vaccination and 3 weeks after vaccination. Following vaccination, the serum bactericidal antibody (SBA) geometric mean titre was significantly increased compared to the prevaccination level in the patient group (8.98 versus 1.63, P<0.001) and the control group (12.13 versus 1.26, P<0.001). All controls had a protective SBA response (SBA titre of >or=8 post-vaccination or rise of >or=4-fold from pre- to post-vaccination), whereas only 16 of 24 patients (66.6%) had a protective response (P=0.014). The non-responder patients included 5 cases with common variable immunodeficiency, two cases with hyper IgM syndrome, and one case with IgG subclass deficiency. This study indicates that some patients with primary antibody deficiencies can produce protective post-vaccination titres similar to the normal population, despite the common perception that patients with primary antibody deficiencies respond poorly to vaccination. This supports the use of polysaccharide-containing vaccines in these patients.
机译：一抗缺乏的特征是免疫球蛋白同种型的血清水平降低以及对各种微生物（包括包囊细菌）的感染敏感性增加。进行这项研究是为了评估这些患者对多糖脑膜炎球菌疫苗的杀菌抗体反应。入选了平均年龄为11.2 +/- 3.5岁的24名抗体缺乏儿童，以及15名性别和年龄相匹配的健康志愿者。所有受试者均接受脑膜炎球菌多糖疫苗A + C;疫苗接种前和疫苗接种后3周采集血样。疫苗接种后，与患者组（8.98比1.63，P <0.001）和对照组（12.13比1.26，P <0.001）的疫苗接种前水平相比，血清杀菌抗体（SBA）的几何平均滴度显着提高。所有对照均具有保护性SBA反应（接种后SBA滴度≥或等于8或接种前至接种后升高>或= 4倍），而24位患者中只有16位（66.6％）具有保护性反应（P ＝ 0.014）。无反应者包括5例具有共同可变免疫缺陷的患者，2例高IgM综合征和1例IgG亚类缺陷的患者。这项研究表明，尽管人们普遍认为一抗缺乏的患者对疫苗的反应较差，但仍能产生与正常人群相似的保护性疫苗后滴度。这支持在这些患者中使用含多糖的疫苗。

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