A chimeric alphavirus RNA replicon gene-based vaccine for human parainfluenza virus type 3 induces protective immunity against intranasal virus challenge

Greer CE; Zhou F; Legg HS; Tang Z; Perri S; Sloan BA; Megede JZ; Uematsu Y; Vajdy M; Polo JM

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A chimeric alphavirus RNA replicon gene-based vaccine for human parainfluenza virus type 3 induces protective immunity against intranasal virus challenge

机译：一种用于人副流感病毒3型的基于嵌合alphavirus RNA复制子基因的疫苗可诱导针对鼻内病毒攻击的保护性免疫

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Parainfluenza virus type 3 (PIV3) infections continue to be a significant health risk for infants, young children, and immunocompromised adults. We describe a gene-based vaccine strategy against PIV3 using replication-defective alphavirus vectors. These RNA replicon vectors, delivered as virus-like particles and expressing the PIV3 hemagglutinin-neuraminidase glycoprotein, were shown to be highly immunogenic in mice and hamsters, inducing PIV3-specific neutralizing antibody responses. Importantly, the replicon particle-based vaccine administered intramuscularly or intranasally protected against mucosal PIV3 challenge in hamsters, preventing virus replication in both nasal turbinates and lungs. These data suggest that the alphavirus replicon platform can be useful for a PIV3 vaccine and possibly other respiratory viruses.

机译：3型副流感病毒（PIV3）感染仍然是婴儿，幼儿和免疫功能低下的成年人的重大健康风险。我们描述了使用复制缺陷型α病毒载体针对PIV3的基于基因的疫苗策略。这些RNA复制子载体以病毒样颗粒的形式表达并表达PIV3血凝素神经氨酸酶糖蛋白，在小鼠和仓鼠中具有高度免疫原性，可诱导PIV3特异性中和抗体反应。重要的是，肌内或鼻内施用的基于复制子颗粒的疫苗可保护仓鼠免受粘膜PIV3攻击，从而防止病毒在鼻甲和肺中复制。这些数据表明，α病毒复制子平台可用于PIV3疫苗以及可能的其他呼吸道病毒。

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《Vaccine》 |2007年第3期|共9页
作者
Greer CE; Zhou F; Legg HS; Tang Z; Perri S; Sloan BA; Megede JZ; Uematsu Y; Vajdy M; Polo JM;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Administration; Intranasal; Alphavirus genetics; Animals; Antibodies; Viral immunology; Cricetinae; Encephalitis Virus; Venezuelan Equine immunology; Enzyme-Linked Immunosorbent Assay; Female; Hemagglutination Inhibition Tests; Mesocricetus; Mice; Mice; Inbred BALB C; Neutralization Tests; Parainfluenza Vaccines immunology; Parainfluenza Virus 3; Human growth amp; development immunology; Paramyxoviridae Infections immunology prevention amp; control; RNA; Viral genetics immunology; Replicon genetics immunology; Sindbis Virus immunology; Vaccines; Synthetic genetics immunology;

机译：给药;鼻内;甲型病毒遗传学;动物;抗体;病毒免疫学;Cricetinae;脑炎病毒;委内瑞拉马免疫学;酶联免疫吸附试验;女性;血凝抑制试验;中cri草;小鼠;小鼠;近交BALB C;中和试验免疫学;流感病毒3;人类生长发育免疫学;副粘病毒科免疫学的预防与控制;RNA;病毒遗传学免疫学;复制子遗传学免疫学;辛德比斯病毒免疫学;疫苗;合成遗传学免疫学;

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专利

1. A chimeric alphavirus RNA replicon gene-based vaccine for human parainfluenza virus type 3 induces protective immunity against intranasal virus challenge [J] . Greer CE, Zhou F, Legg HS, Vaccine . 2007,第3期

机译：一种用于人副流感病毒3型的基于嵌合alphavirus RNA复制子基因的疫苗可诱导针对鼻内病毒攻击的保护性免疫
2. A chimeric glycoprotein formulated with a combination adjuvant induces protective immunity against both human respiratory syncytial virus and parainfluenza virus type 3 [J] . Garg R., Brownlie R., Latimer L., Antiviral Research . 2018,第期

机译：用组合佐剂配制的嵌合糖蛋白诱导人类呼吸道合胞病毒和Parainfluenza病毒类型3的保护性免疫
3. Human parainfluenza virus type 3 expressing the respiratory syncytial virus pre-fusion F protein modified for virion packaging yields protective intranasal vaccine candidates [J] . Xueqiao Liu, Bo Liang, Xiang Liu, PLoS One . 2020,第2期

机译：人类腹股沟病毒类型3表达呼吸合胞病毒预融合F型蛋白修饰用于病毒藻包装产生保护性鼻内疫苗候选物
4. Development of an alphavirus replicon particle-based vaccine against classical swine fever virus [C] . J. Dustin Loy, Mark Mogler, Jill Gander, Annual^Meeting of the American Association^of^Swine^Veterinarians. . 2013

机译：对古典猪瘟病毒的alphavirus复制子颗粒疫苗的研制
5. Recombinant fowlpox-laryngotracheitis vaccine and recombinant herpes virus of turkey-laryngotracheitis vaccine induced immunity against infectious laryngotracheitis virus challenge. [D] . Luengo C., Amelia C. 1998

机译：重组鸡痘-喉气管炎疫苗和重组疱疹病毒-土耳其-喉气管炎疫苗可诱导抵抗传染性喉气管炎病毒攻击的免疫力。
6. Combined Alphavirus Replicon Particle Vaccine Induces Durable and Cross-Protective Immune Responses against Equine Encephalitis Viruses [O] . Douglas S. Reed, Pamela J. Glass, Russell R. Bakken, 2014

机译：联合的甲病毒复制子颗粒疫苗诱导针对马脑炎病毒的持久和交叉保护性免疫反应
7. Human parainfluenza virus type 3 expressing the respiratory syncytial virus pre-fusion F protein modified for virion packaging yields protective intranasal vaccine candidates [O] . Xueqiao Liu, Bo Liang, Xiang Liu, 2020

机译：人类Parainfluenza病毒型3表达呼吸道合胞病毒预融合F型蛋白修饰用于病毒藻包装，产生保护性鼻内疫苗候选物
8. Multi-Agent Alphavirus DNA Vaccine Delivered by Intramuscular Electroporation Elicits Robust and Durable Virus Specific Immune Responses in Mice and Rabbits and Completely Protects Mice against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenges. [R] . Dupuy, L. C., Richards, M. J., Livingston, B. D., 2016

机译：通过肌内电穿孔提供的多剂甲病毒DNa疫苗在小鼠和家兔中引发健壮和耐久的病毒特异性免疫应答，并完全保护小鼠免受致命的委内瑞拉，西方和东方马脑炎病毒气溶胶挑战。

A chimeric alphavirus RNA replicon gene-based vaccine for human parainfluenza virus type 3 induces protective immunity against intranasal virus challenge

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