Perspectives on the development of a therapeutic HER-2 cancer vaccine

Renard V; Leach DR

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Perspectives on the development of a therapeutic HER-2 cancer vaccine

机译：关于治疗性HER-2癌症疫苗开发的观点

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With good reason, the majority of cancer vaccines tested, or being tested, have targeted the induction of anti-tumour CTL responses. However, the clinical success of monoclonal antibodies such as Rituximab/CD20, Trastuzumab/HER-2, Cetuximab/EGFR and Bevacisumab/VEGF suggests that their respective targets may also be relevant for cancer vaccines aiming at the induction of an effective humoral anti-tumour response to mimic, or potentially improve upon, the effects of monoclonal therapies. We report here an overview of the development of a protein vaccine targeting HER-2eu, with an emphasis on the immunologic results obtained from the testing of the vaccine in animal models of disease and in toxicology programs, to its evaluation in three clinical trials in breast cancer patients.

机译：有充分的理由，大多数已测试或正在测试的癌症疫苗都针对诱导抗肿瘤CTL反应。但是，单克隆抗体（如利妥昔单抗/ CD20，曲妥珠单抗/ HER-2，西妥昔单抗/ EGFR和贝伐单抗/ VEGF）的临床成功表明，它们各自的靶标也可能与旨在诱导有效的体液抗肿瘤的癌症疫苗有关。模仿或可能改善单克隆疗法的效果。我们在此报告针对HER-2 / neu的蛋白疫苗的开发概况，重点是从在疾病动物模型和毒理学程序中测试该疫苗所获得的免疫学结果，以及在三个临床试验中对其进行评估的结果在乳腺癌患者中。

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《Vaccine》 |2007年第2期|共7页
作者
Renard V; Leach DR;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Animals; Antineoplastic Agents administration amp; dosage adverse effects therapeutic use; Breast Neoplasms chemistry pathology; Cancer Vaccines administration amp; dosage therapeutic use; Drug Delivery Systems; Female; Humans; Mice; Models; Animal; Receptor; erbB-2 genetics immunology;

机译：动物;抗肿瘤药的给药和剂量不良反应的治疗用途;乳腺肿瘤化学病理学;癌症疫苗的给药和剂量治疗的用途;药物输送系统;女性;人类;小鼠;模型;动物;受体;erbB-2遗传学免疫学;

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专利

1. Perspectives on the development of a therapeutic HER-2 cancer vaccine [J] . Renard V, Leach DR Vaccine . 2007,第Suppla2期

机译：关于治疗性HER-2癌症疫苗开发的观点
2. Anti-Tumor Effects of Peptide Therapeutic and Peptide Vaccine Antibody Co-targeting HER-1 and HER-2 in Esophageal Cancer (EC) and HER-1 and IGF-1R in Triple-Negative Breast Cancer (TNBC) [J] . Eduardo Sanabria-Figueroa, Jay Overholser, Kristen Henkins Ambegaokar, Vaccines . 2015,第3期

机译：靶向HER-1和HER-2的多肽治疗药物和肽疫苗抗体在食管癌（EC）和三阴性乳腺癌（TNBC）中的HER-1和IGF-1R的抗肿瘤作用
3. Targeted therapeutic remodeling of the tumor microenvironment improves an HER-2 DNA vaccine and prevents recurrence in a murine breast cancer model. [J] . Liao D, Liu Z, Wrasidlo WJ, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2011,第17期

机译：肿瘤微环境的靶向治疗重塑可改善HER-2 DNA疫苗并预防鼠类乳腺癌模型的复发。
4. HER1 THERAPEUTIC CANCER VACCINE: AN ACTIVE IMMUNOTHERAPY TREATMENT FOR PATIENTS WITH TUMORS EXPRESSING THE RECEPTOR OF EPIDERMAL GROWTH FACTOR (EGF-R) [C] . Eduardo Suarez, Belinda Sanchez, Zaima Mazorra, Conference on vaccine technology VI . 2018

机译：HER1癌症治疗疫苗：一种针对表皮生长因子（EGF-R）受体的肿瘤的主动免疫疗法
5. Dendritic cell-based cancer vaccines using adenovirally mediated expression of the HER-2/neu gene and apoptotic tumor cells expressing heat shock protein 70. [D] . Chan, Tim. 2006

机译：使用HER-2 / neu基因的腺病毒介导表达和表达热休克蛋白70的凋亡肿瘤细胞的基于树突细胞的癌症疫苗。
6. Anti-Tumor Effects of Peptide Therapeutic and Peptide Vaccine Antibody Co-targeting HER-1 and HER-2 in Esophageal Cancer (EC) and HER-1 and IGF-1R in Triple-Negative Breast Cancer (TNBC) [O] . Jay Overholser, Kristen Henkins Ambegaokar, Siobhan M. Eze, 2015

机译：靶向HER-1和HER-2的肽治疗和肽疫苗抗体在食管癌（EC）和三阴性乳腺癌（TNBC）中的HER-1和IGF-1R的抗肿瘤作用
7. Anti-Tumor Effects of Peptide Therapeutic and Peptide Vaccine Antibody Co-targeting HER-1 and HER-2 in Esophageal Cancer (EC) and HER-1 and IGF-1R in Triple-Negative Breast Cancer (TNBC) [O] . Jay Overholser, Kristen Henkins Ambegaokar, Siobhan M. Eze, 2015

机译：肽治疗和肽疫苗抗体共同靶向HER-1和HER-2在食管癌（EC）和HER-1和IGF-1R在三阴性乳腺癌（TNBC）中的抗肿瘤作用

Perspectives on the development of a therapeutic HER-2 cancer vaccine

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