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首页> 外文期刊>Vaccine >Age-specific seroprevalence of serogroup C meningococcal serum bactericidal antibody activity and serogroup A, C, W135 and Y-specific IgG concentrations in the Turkish population during 2005
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Age-specific seroprevalence of serogroup C meningococcal serum bactericidal antibody activity and serogroup A, C, W135 and Y-specific IgG concentrations in the Turkish population during 2005

机译：2005年土耳其人群中血清C组脑膜炎球菌血清杀菌抗体活性以及血清A，C，W135和Y特异性IgG浓度的年龄特异性血清阳性率

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Like many other developing countries; there is no accurate information about the antibody levels against Neisseria meningitidis in Turkey. We collected serum samples from four health centers located in different geographic regions and stratified according to age in order to obtain a baseline seroprevalence of protective antibodies to meningococcal serogroup C and provide data on seroprevalence of IgG antibodies to serogroups A, C, W135 and Y. Sera were tested for serum bactericidal antibodies (SBA) to serogroup C meningococci using rabbit serum as the complement source and by a bead based assay for serogroup A, C, W135 and Y-specific IgG. It was observed that 30% and 12% of individuals within the study population had SBA titers of >/=8 and >/=128, respectively. Overall; at least 70% of the population are susceptible (SBA titer <8) to meningococcal serogroup C disease. The rate of susceptibility was highest in infants aged 7-12 months and young children (1-4 years). Regardless of age, for serogroup A, C, W135 and Y, 60.5%, 27.2%, 12.3% and 19.2% of subjects, respectively, had serogroup-specific IgG concentrations >/=2mug/mL. These data highlight that a large proportion of the Turkish population are susceptible to serogroups C, W135 and Y and should be considered, along with serogroup-specific disease incidence data, in future decisions on possible meningococcal vaccination programmes.
机译：像许多其他发展中国家一样;没有关于土耳其针对脑膜炎奈瑟氏球菌的抗体水平的准确信息。我们从位于不同地理区域的四个卫生中心收集血清样本，并根据年龄进行分层，以获取针对脑膜炎球菌血清群C的保护性抗体的基线血清阳性率，并提供针对血清群A，C，W135和Y的IgG抗体血清阳性率的数据。使用兔血清作为补体来源，并通过基于珠的化验，针对血清群A，C，W135和Y特异性IgG，测试血清针对血清群C的脑膜炎球菌的血清杀菌抗体（SBA）。观察到，研究人群中30％和12％的个体的SBA效价分别为> / = 8和> / = 128。总体;至少有70％的人群对C型脑膜炎球菌易感（SBA效价<8）。在7-12个月大的婴儿和年幼的儿童（1-4岁）中，药敏率最高。无论年龄，对于血清群A，C，W135和Y，分别有60.5％，27.2％，12.3％和19.2％的血清群特异性IgG浓度> / = 2mug / mL。这些数据表明，土耳其人口中的很大一部分人群易受C，W135和Y血清群感染，因此在未来可能的脑膜炎球菌疫苗接种计划决策中应将其与血清群特异性疾病发病率数据一起考虑。

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