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首页> 外文期刊>Vaccine >Expression of cytokine genes following pre- and post-hatch immunization of chickens with herpesvirus of turkeys.
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Expression of cytokine genes following pre- and post-hatch immunization of chickens with herpesvirus of turkeys.

机译：用火鸡疱疹病毒对鸡进行孵化前后的细胞因子基因表达。

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摘要

Induction of immune response as characterised by expression of cytokine genes in the spleen following immunization of pre- and post-hatch chickens with herpesvirus of turkeys (HVT) vaccine was studied. The pattern of expression of IFN-gamma and IL-10 genes in pre-hatch immunized chickens was different from that observed in post-hatch HVT immunized chickens. This expression pattern of cytokine genes was associated with significantly higher HVT transcripts in pre-hatch immunized chickens than in post-hatch immunized chickens. In conclusion, HVT immunization in chickens, irrespective of the age of immunization, stimulates host response characterised by the expression of cytokine genes, such as IFN-gamma and IL-10 in the spleen. However, the age of immunization appears to influence the temporal pattern of IFN-gamma and IL-10 expression as well as replication of HVT.
机译：研究了以火鸡疱疹病毒（HVT）疫苗免疫孵化前后鸡的脾脏中细胞因子基因表达特征的免疫应答诱导。孵化前免疫的鸡中IFN-γ和IL-10基因的表达模式与孵化后HVT免疫的鸡中观察到的模式不同。与孵化后免疫的鸡相比，这种细胞因子基因的表达方式与孵化前免疫的鸡的HVT转录显着相关。总之，无论免疫年龄多高，鸡的HVT免疫都能刺激以细胞因子基因（如IFN-γ和IL-10）在脾脏中表达为特征的宿主反应。但是，免疫年龄似乎会影响IFN-γ和IL-10表达的时间模式以及HVT的复制。

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