Mixing of M segment DNA vaccines to Hantaan virus and Puumala virus reduces their immunogenicity in hamsters.

Spik KW; Badger C; Mathiessen I; Tjelle T; Hooper JW; Schmaljohn C

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Mixing of M segment DNA vaccines to Hantaan virus and Puumala virus reduces their immunogenicity in hamsters.

机译：将针对汉坦病毒和Puumala病毒的M段DNA疫苗混合使用，会降低它们在仓鼠中的免疫原性。

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To determine if DNA vaccines for two hantaviruses causing hemorrhagic fever with renal syndrome, Hantaan virus and Puumala virus, are immunogenic when given in combination, we delivered them to hamsters separately or as mixtures by gene gun or by electroporation. Both vaccines elicited neutralizing antibodies when given alone but when they were delivered as a mixture, antibodies to only one of the two hantaviruses could be detected. In contrast, if the DNAs were given as separate vaccinations to a single animal, responses to both were observed. These studies suggest that the two DNA vaccines will need to be given as separate administrations.

机译：为了确定结合使用两种引起肾综合征出血热的汉坦病毒（汉坦病毒和普马马拉病毒）的DNA疫苗是否具有免疫原性，我们将它们分开或通过基因枪或电穿孔的混合物递送到仓鼠中。两种疫苗单独给予时均会产生中和抗体，但是当它们以混合物形式交付时，只能检测到两种汉坦病毒之一的抗体。相反，如果将DNA作为单独的疫苗接种给一只动物，则会观察到对它们的反应。这些研究表明，两种DNA疫苗需要分开给药。

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《Vaccine》 |2008年第40期|共5页
作者
Spik KW; Badger C; Mathiessen I; Tjelle T; Hooper JW; Schmaljohn C;
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中图分类卫生标准、卫生检查、医药管理;
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1. Mixing of M segment DNA vaccines to Hantaan virus and Puumala virus reduces their immunogenicity in hamsters. [J] . Spik KW, Badger C, Mathiessen I, Vaccine . 2008,第40期

机译：将针对汉坦病毒和Puumala病毒的M段DNA疫苗混合使用，会降低它们在仓鼠中的免疫原性。
2. Immunogenicity of combination DNA vaccines for Rift Valley fever virus, tick-borne encephalitis virus, Hantaan virus, and Crimean Congo hemorrhagic fever virus [J] . Spik K, Shurtleff A, McElroy AK, Vaccine . 2006,第21期

机译：裂谷热病毒，tick传脑炎病毒，汉坦病毒和克里米亚刚果出血热病毒联合DNA疫苗的免疫原性
3. Fusion with extracellular domain of cytotoxic T-lymphocyte-associated-antigen 4 leads to enhancement of immunogenicity of Hantaan virus DNA vaccines in C57BL/6 mice [J] . Feng Liu, Mifang Liang, Shouchun Cao, Virology Journal . 2011,第1期

机译：与细胞毒性T淋巴细胞相关抗原4的胞外域融合导致C57BL / 6小鼠汉坦病毒DNA疫苗的免疫原性增强
4. DNA Vaccines Co-expressing Containing Hsp70 and GP5/M Protein of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Display Enhanced Immunogenicity [C] . Zuo Lan, Yan Qi-Gui, Lei Yan, International Conference on Mechanical Engineering and Intelligent Systems . 2012

机译：DNA疫苗共同含有HSP70和猪生殖和呼吸综合征病毒（PRRSV）的GP5 / M蛋白显示出增强的免疫原性
5. A rhesus monkey model of respiratory syncytial virus (RSV) to evaluate the immunogenicity and protective efficacy of a DNA vaccine. [D] . Vaughan, Kerrie Colleen McArthur. 2002

机译：呼吸道合胞病毒（RSV）的恒河猴模型，用于评估DNA疫苗的免疫原性和保护功效。
6. A vaccinia virus-vectored Hantaan virus vaccine protects hamsters from challenge with Hantaan and Seoul viruses but not Puumala virus. [O] . Y K Chu, G B Jennings, C S Schmaljohn 1987

机译：痘苗病毒载体的汉坦病毒疫苗可以保护仓鼠免受汉坦病毒和汉城病毒的攻击，而不能抵抗普马马拉病毒的攻击。
7. Mixing of M segment DNA vaccines to Hantaan virus and Puumala virus reduces their immunogenicity in hamsters [O] . Spik, Kristin, Badger, Catherine, Mathiessen, Iacob, 2008

机译：m段DNa疫苗与汉坦病毒和普马拉病毒的混合降低了它们在仓鼠中的免疫原性
8. Mixing of M Segment DNA Vaccines to Hantaan Virus and Puumala Virus Reduces Their Immunogenicity in Hamsters [R] . Spik, K. W., Badger, C., Mathiessen, I., 2008

机译：将m段DNa疫苗与汉坦病毒和普马拉病毒混合可降低其在仓鼠中的免疫原性

Mixing of M segment DNA vaccines to Hantaan virus and Puumala virus reduces their immunogenicity in hamsters.

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