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首页> 外文期刊>Vaccine >Kinetics of cell migration to the dermis and hypodermis in dogs vaccinated with antigenic compounds of Leishmania braziliensis plus saponin.
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Kinetics of cell migration to the dermis and hypodermis in dogs vaccinated with antigenic compounds of Leishmania braziliensis plus saponin.

机译：接种了巴西利什曼原虫抗原和皂苷的抗原化合物的狗的细胞迁移到真皮和皮下的动力学。

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摘要

The search for new immunobiologicals against canine visceral leishmaniasis (CVL) has intensified in the last decade. However, it still remains to be elucidated that mechanisms of the innate immune response in situ after immunization (a.i.). The aim of this study was to investigate the kinetics of cell migration in the skin dogs with distinct antigenic compounds of the LBSap vaccine. Our major findings indicated that saponin adjuvant alone or combined with Leishmania braziliensis antigen induced strong local acute inflammatory reaction. However, these reactions not progressed to ulcerated lesions. Overall, the cell profile found in Sap and LBSap was composed of neutrophils, lymphocytes and eosinophils. There was also increased production of iNOS in Sap and LBSap groups. Thus, we can conclude that dogs immunized by LBSap and the saponin adjuvant elicited a potential innate-immune activations status compatible with effective control of the resistance to infection by Leishmania and contributing to a better understanding of the innate-immunity events induced by the LBSap vaccine.
机译：在过去的十年中，针对犬内脏利什曼病（CVL）的新的免疫生物学研究日益深入。然而，仍然有待阐明的是免疫后原位免疫反应的原位机制（a.i.）。这项研究的目的是研究具有LBSap疫苗独特抗原化合物的皮狗中细胞迁移的动力学。我们的主要发现表明，皂苷佐剂单独或与巴西利什曼原虫抗原结合可引起强烈的局部急性炎症反应。但是，这些反应并未发展为溃疡性病变。总体而言，在Sap和LBSap中发现的细胞谱由嗜中性粒细胞，淋巴细胞和嗜酸性粒细胞组成。 Sap和LBSap组的iNOS产量也增加了。因此，我们可以得出结论，用LBSap和皂苷佐剂免疫的狗引发了潜在的先天免疫激活状态，与有效控制利什曼原虫对感染的抵抗力兼容，并有助于更好地了解LBSap疫苗诱导的先天免疫事件。

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