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首页> 外文期刊>Vaccine >Despite Leishvaccine and Leishmune trigger distinct immune profiles, their ability to activate phagocytes and CD8+ T-cells support their high-quality immunogenic potential against canine visceral leishmaniasis.
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Despite Leishvaccine and Leishmune trigger distinct immune profiles, their ability to activate phagocytes and CD8+ T-cells support their high-quality immunogenic potential against canine visceral leishmaniasis.

机译：尽管Leishvaccine和Leishmune触发了独特的免疫谱，但它们激活吞噬细胞和CD8 + T细胞的能力仍支持其针对犬内脏利什曼病的高质量免疫原性潜力。

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Phenotypic features of peripheral blood leukocytes have been investigated as a pre-requisite to characterize the protective immunity attributed to both Leishvaccine and LeishmuneReg.. Our results showed that either those vaccine were accompanied by distinct profiles on innate immune compartment. While Leishvaccine promoted early changes in phenotypic features of neutrophils and eosinophils with late involvement of monocytes, LeishmuneReg. induced early and persistent activation of neutrophils and monocytes, without changes on eosinophil activation status. Regarding the adaptive immunity, Leishvaccine sponsored a mixed profile, associated with phenotypic changes of T and B-lymphocytes. Major phenotypic changes in CD4+ T-cells with transient activation of CD8+ T-cell, besides decreased frequency of B-cell expressing CD32 were the hallmark of Leishvaccine. In contrast, LeishmuneReg. was associated with phenotypic changes in T-lymphocytes, particularly in CD8+ T-cells, and selective up-regulation of CD3+CD5+LowCD8+ cells. We hypothesized that this dissimilar alteration in immunological events would represent phenomenon directly related with the molecular nature of these vaccines besides the distinct adjuvants employed. However, it is important to emphasize that both immunobiologicals are able to activate phagocytes and CD8+ T-cells and therefore could be considered priority vaccines with a high-quality immunogenic potential against CVL.
机译：已经研究了外周血白细胞的表型特征，作为表征归因于利什曼疫苗和利什曼原子的保护性免疫的先决条件。我们的结果表明，这两种疫苗在先天免疫区室中均具有不同的特征。 Leishvaccine促进中性粒细胞和嗜酸性粒细胞表型特征的早期改变，而单核细胞的晚期参与，LeishmuneReg。诱导嗜中性粒细胞和单核细胞的早期和持续激活，而嗜酸性粒细胞的激活状态没有改变。关于适应性免疫，Leishvaccine赞助了一个与T和B淋巴细胞的表型变化相关的混合模式。 Leishvaccine的标志是CD4 + T细胞的主要表型改变以及CD8 + T细胞的瞬时激活，此外B细胞表达CD32的频率降低。相反，LeishmuneReg。与T淋巴细胞，特别是CD8 + T细胞的表型变化和CD3 + CD5 + LowCD8 +细胞的选择性上调有关。我们假设免疫事件的这种不同变化将代表与所用疫苗的佐剂不同的，与这些疫苗的分子性质直接相关的现象。但是，必须强调的是，这两种免疫生物学药都能够激活吞噬细胞和CD8 + T细胞，因此可以被视为具有针对CVL的高质量免疫原性潜力的优先疫苗。

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