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Hepatitis A virus seroprevalence by age and world region, 1990 and 2005

机译:1990年和2005年按年龄和世界地区划分的甲型肝炎病毒血清流行率

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Objective: To estimate current age-specific rates of immunity to hepatitis A virus (HAV) in world regions by conducting a systematic review and meta-analysis of published data. The estimation of the global burden of hepatitis A and policies for public health control are dependent on an understanding of the changing epidemiology of this viral infection.Methods: Age-specific IgG anti-HAV seroprevalence data from more than 500 published articles were pooled and used to fit estimated age-seroprevalence curves in 1990 and 2005 for each of 21 world regions (as defined by the Global Burden of Disease 2010 Study).Findings: High-income regions (Western Europe, Australia, New Zealand, Canada, the United States, Japan, the Republic of Korea, and Singapore) have very low HAV endemicity levels and a high proportion of susceptible adults, low-income regions (sub-Saharan Africa and parts of South Asia) have high endemicity levels and almost no susceptible adolescents and adults, and most middle-income regions have a mix of intermediate and low endemicity levels.Conclusion: Anti-HAV prevalence estimates in this analysis suggest that middle-income regions in Asia, Latin America, Eastern Europe, and the Middle East currently have an intermediate or low level of endemicity. The countries in these regions may have an increasing burden of disease from hepatitis A, and may benefit from new or expanded vaccination programs
机译:目的:通过对发表的数据进行系统的回顾和荟萃分析,估算世界地区当前针对特定年龄的甲型肝炎病毒(HAV)免疫率。估计全球甲型肝炎负担和公共卫生控制政策取决于对这种病毒感染流行病学变化的理解。方法:汇集并使用了来自500篇已发表文章的特定年龄IgG抗HAV血清阳性数据以适应1990年和2005年21个世界区域(根据《 2010年全球疾病负担》研究定义)的年龄-血清流行率曲线。发现:高收入区域(西欧,澳大利亚,新西兰,加拿大,美国) ,日本,大韩民国和新加坡)的HAV流行率很低,易感成年人的比例很高;低收入地区(撒哈拉以南非洲和南亚的部分地区)的流行率很高,几乎没有易感的青少年,成人和大多数中等收入地区的混合水平介于中低等。结论:此分析中的抗HAV患病率估计值表明,亚洲中等收入地区(拉丁美洲,拉丁美洲)例如,东欧和中东地区的流行程度中等或较低。这些地区的国家可能会增加甲型肝炎的疾病负担,并可能受益于新的或扩大的疫苗接种计划

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