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首页> 外文期刊>Vaccine >Patterns of emergency room visits, admissions and death following recommended pediatric vaccinations-A population based study of 969,519 vaccination events
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Patterns of emergency room visits, admissions and death following recommended pediatric vaccinations-A population based study of 969,519 vaccination events

机译：推荐的儿科疫苗接种后的急诊室就诊，入院和死亡方式-基于人群的969,519接种事件研究

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Background: The risk of immediate adverse events due to the inflammation created by a vaccine is a potential concern for pediatric vaccine programs.Methods: We analyzed data on children born between March 2006 and March 2009 in the province of Ontario. Using the self-controlled case series design, we examined the risk of the combined endpoint of emergency room visit and hospital admission in the immediate 3 days post vaccination to a control period 9-18 days after vaccination. We examined the end points of emergency room visits, hospital admissions and death separately as secondary outcomes.Results: We examined 969,519 separate vaccination events. The relative incidence of our combined end point was 0.85 (0.80-0.90) for vaccination at age 2 months, 0.74 (0.69-0.79) at age 4 months and 0.68 (0.63-0.72) at age 6 months. The relative incidence was reduced for the individual endpoints of emergency room visits, admissions and death. There were 5 or fewer deaths in the risk interval of all 969,519 vaccination events. In a post hoc analysis we observed a large reduction in events in the immediate 3 days prior to vaccination suggesting a large healthy vaccinee effect.Conclusion: There was no increased incidence of the combined end point of emergency room visits and hospitalizations in the 3-day period immediately following vaccination, nor for individual endpoints or death. The health vaccinee effect could create the perception of worsening health following vaccines in the absence of any vaccine adverse effect and could also mask an effect in the immediate post-vaccination period
机译：背景：由于疫苗引起的炎症而引起的直接不良事件的风险是儿童疫苗项目的潜在问题。方法：我们分析了安大略省2006年3月至2009年3月之间出生的儿童的数据。使用自我控制的病例系列设计，我们检查了在接种疫苗后3天到接种疫苗后9-18天的控制期间内，急诊就诊和入院综合终点的风险。我们分别检查了急诊室就诊，住院和死亡的终点作为次要结果。结果：我们检查了969,519次单独的疫苗接种事件。在2个月大时，我们联合终点的相对发生率为0.85（0.80-0.90），在4个月大时为0.74（0.69-0.79），在6个月大时为0.68（0.63-0.72）。急诊就诊，入院和死亡的各个终点的相对发生率均降低。在所有969,519次接种疫苗的风险间隔中，有5例或更少的死亡。在事后分析中，我们观察到疫苗接种前3天事件的发生率大大降低，表明对健康的疫苗接种效果很大。结论：在急诊室就诊和住院的3天内，合并终点的发生率没有增加疫苗接种后立即结束，也不会出现个别终点或死亡。在没有任何疫苗不良影响的情况下，健康疫苗接种者的作用可能会导致疫苗接种后健康恶化的感觉，也可能掩盖疫苗接种后即刻的作用

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