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Sero-epidemiology of measles in general population in Jiangsu province of China: Application of mixture models to interpret the results from a cross-sectional study

机译：中国江苏省普通人群的麻疹血清流行病学：应用混合模型解释横断面研究的结果

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摘要

A cross-sectional survey of measles seroprevalence in general population was conducted in Jiangsu province of China. Data were analyzed by employing commercial ELISA cut-offs and mixture models. The results suggest that the overall measles seroprevalence rate in Jiangsu province (88.7%. 95% confidence interval 87.7-89.6%) was lower than the level believed to be necessary for the elimination of measles. Mixture model could provide a more comprehensive understanding of these results by investigating the different levels of antibody response to vaccination or natural infection in the population, and suggest that the vaccine-induced antibody levels may wane with time. Additional actions should be conducted in the young adult cohorts aged 15-19 years in center region. SIAs for susceptible birth cohorts over the whole province are urgent
机译：在中国江苏省对普通人群的麻疹血清阳性率进行了横断面调查。通过采用商业ELISA临界值和混合物模型分析数据。结果表明，江苏省的总体麻疹血清阳性率（88.7％。95％置信区间为87.7-89.6％）低于消除麻疹所需的水平。混合物模型可以通过调查人群中针对疫苗接种或自然感染的抗体反应的不同水平来提供对这些结果的更全面的理解，并表明疫苗诱导的抗体水平可能随着时间而消失。在中部地区年龄在15-19岁之间的年轻成年人群体应采取其他措施。整个省范围内针对易感人群的SIA迫在眉睫

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