Protective CTL response is induced in the absence of CD4(+) T cells andIFN-gamma by gene gun DNA vaccination with a minigene encoding a CTLepitope of Listeria monocytogenes

Yoshida A; Nagata T; Uchijima M; Koide Y

首页> 外文期刊>Vaccine >Protective CTL response is induced in the absence of CD4(+) T cells andIFN-gamma by gene gun DNA vaccination with a minigene encoding a CTLepitope of Listeria monocytogenes

【24h】

Protective CTL response is induced in the absence of CD4(+) T cells andIFN-gamma by gene gun DNA vaccination with a minigene encoding a CTLepitope of Listeria monocytogenes

机译：在不存在CD4（+）T细胞和IFN-γ的情况下，通过基因枪DNA疫苗接种编码李斯特菌单核细胞增生性李斯特菌的小基因诱导保护性CTL反应。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Our work was undertaken to learn the mechanism of induction of protective cytotoxic T lymphocytes (CTL) by gene gun DNA vaccination with p91m encoding an H-2K(d)-restricted T cell epitope of listeriolysin O (LLO). Vaccination with p91m induced vigorous antigen-specific CD8(+) CTL that produce IFN-gamma and was able to confer partial protection against listerial challenge. However, the p91m-induced protective immunity was revealed to be independent of the IFN-gamma and CD4(+) T cell help. The CTL induction is also suggested to require neither adjuvant activity of the plasmid used nor IFN-gamma. The data may be feasible for the design of CTL inducing vaccines in various immunodeficiencies.

机译：我们的工作旨在研究通过基因枪DNA疫苗接种编码H-2K（d）限制的李斯特菌溶血素O（LLO）的T细胞表位的p91m来诱导保护性细胞毒性T淋巴细胞（CTL）的机制。用p91m进行疫苗接种可诱导产生强烈的抗原特异性CD8（+）CTL，从而产生IFN-γ，并且能够针对李斯特菌激发提供部分保护。然而，揭示p91m诱导的保护性免疫独立于IFN-γ和CD4（+）T细胞的帮助。还建议CTL诱导既不需要所用质粒的佐剂活性也不需要IFN-γ。该数据对于设计各种免疫缺陷的CTL诱导疫苗可能是可行的。

著录项

来源
《Vaccine》 |2001年第30期|共10页
作者
Yoshida A; Nagata T; Uchijima M; Koide Y;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Gene gun; Cytotoxic t lymphocytes; Minigene; Natural-killer-cells; Interferon-gamma; Dendritic cells; Immune-responses; Lymphocytes-t; In-vivo; Intracellular bacterium; Immunostimulatory dna; Envelope protein; Mammalian-cells;

机译：基因枪;细胞毒性t淋巴细胞;小基因;自然杀伤细胞;干扰素-γ;树突状细胞;免疫反应;淋巴细胞-t;体内;细胞内细菌;免疫刺激性dna;包膜蛋白;哺乳动物细胞;

相似文献

外文文献
专利

1. Protective CTL response is induced in the absence of CD4(+) T cells andIFN-gamma by gene gun DNA vaccination with a minigene encoding a CTLepitope of Listeria monocytogenes [J] . Yoshida A, Nagata T, Uchijima M, Vaccine . 2001,第30期

机译：在不存在CD4（+）T细胞和IFN-γ的情况下，通过基因枪DNA疫苗接种编码李斯特菌单核细胞增生性李斯特菌的小基因诱导保护性CTL反应。
2. Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help. [J] . Grenningloh R, Darj A, Bauer H, Scandinavian journal of immunology. . 2008,第6期

机译：脂质体包裹的抗原诱导针对单核细胞增生李斯特菌的保护性CTL反应，而独立于CD4 + T细胞的帮助。
3. DNA Sequences Encoding CD4+ and CD8+T-Cell Epitopes Are Important for Efficient Protective Immunity Induced by DNA Vaccination with a Trypanosoma cruziGene [J] . Adriana E. Fujimura, Sheila S. Kinoshita, Vera L. Pereira-Chioccola, Infection and immunity . 2001,第9期

机译：编码CD4 +和CD8 + T细胞表位的DNA序列对于锥虫锥虫DNA疫苗接种诱导的有效保护性免疫很重要
4. Innate and adaptive immune responses to Listeria monocytogenes in the presence and absence of gammadelta T cells. [D] . Freeman, Molly M. 2005

机译：存在和不存在γδT细胞时对单核细胞增生李斯特菌的先天性和适应性免疫反应。
5. DNA Sequences Encoding CD4+ and CD8+ T-Cell Epitopes Are Important for Efficient Protective Immunity Induced by DNA Vaccination with a Trypanosoma cruzi Gene [O] . Adriana E. Fujimura, Sheila S. Kinoshita, Vera L. Pereira-Chioccola, 2001

机译：编码CD4 +和CD8 + T细胞表位的DNA序列对于锥虫锥虫基因的DNA疫苗接种诱导的有效保护性免疫很重要
6. Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help. [O] . Grenningloh, R, Darj, A, Bauer, H, 2008

机译：脂质体包裹的抗原诱导针对单核细胞增生李斯特菌的保护性CTL反应，而独立于CD4 + T细胞的帮助。

Protective CTL response is induced in the absence of CD4(+) T cells andIFN-gamma by gene gun DNA vaccination with a minigene encoding a CTLepitope of Listeria monocytogenes

摘要

著录项

相似文献

相关主题

期刊订阅