B cell responses in gastric antrum and duodenum following oral inactivated Helicobacter pylori whole cell (HWC) vaccine and LTR192G in H-pylori seronegative individuals

Losonsky GA; Kotloff KL; Walker RI

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B cell responses in gastric antrum and duodenum following oral inactivated Helicobacter pylori whole cell (HWC) vaccine and LTR192G in H-pylori seronegative individuals

机译：口服灭活幽门螺杆菌全细胞疫苗和L幽门螺杆菌阴性个体的LTR192G后胃窦和十二指肠的B细胞反应

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To investigate whether B cell-specific responses could be elicited in the gastric mucosa of Helicobacterpylori (HP) naive subjects, five volunteers ingested three doses of a HP killed whole cell (HWC) vaccine with 25 mug of recombinant heat-labile toxin (LTR192G). TWO Of three subjects had detectable LTR192G and HWC IgA antibody secreting cell (ASC) gastric responses. LTR192G and HWC responses in duodenal were 5-14-fold higher than those detected in antral biopsies (P < 0.01 and P = 0.05, respectively). These results provide the first evidence that specific gastric B cell responses can be induced in HP-non-infected individuals following oral immunization.

机译：为了研究是否可以在未感染幽门螺杆菌（HP）的胃黏膜中引起B细胞特异性应答，五名志愿者摄入了三剂HP杀死的全细胞（HWC）疫苗和25杯重组热不稳定毒素（LTR192G）。三名受试者中有两名具有可检测的LTR192G和HWC IgA抗体分泌细胞（ASC）胃反应。十二指肠中的LTR192G和HWC响应比肛门活检中的响应高5-14倍（分别为P <0.01和P = 0.05）。这些结果提供了第一个证据，即口服免疫后可在未感染HP的个体中诱导特异性胃B细胞应答。

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《Vaccine》 |2003年第6期|共4页
作者
Losonsky GA; Kotloff KL; Walker RI;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Helicobacter pylori; B cell responses; Gastric antrum and duodenum; Cholera vaccination; Adjuvant; Immunogenicity; Humans; Toxin;

机译：幽门螺杆菌;B细胞反应;胃窦和十二指肠;霍乱疫苗;佐剂;免疫原性;人类;毒素;

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1. B cell responses in gastric antrum and duodenum following oral inactivated Helicobacter pylori whole cell (HWC) vaccine and LTR192G in H-pylori seronegative individuals [J] . Losonsky GA, Kotloff KL, Walker RI Vaccine . 2003,第5a6期

机译：口服灭活幽门螺杆菌全细胞疫苗和L幽门螺杆菌阴性个体的LTR192G后胃窦和十二指肠的B细胞反应
2. FOXP3-expressing CD4+ T cell Numbers Increase in Areas of Duodenal Gastric Metaplasia and are Associated to CD4~+ T-cell Aggregates in the Duodenum of Helicobacter pylori-infected Duodenal Ulcer Patients [J] . Bert Kindlund, _sa Sj_ling, Malin Hansson, Helicobacter . 2009,第3期

机译：FOXP3表达的CD4 + T细胞数目在十二指肠胃化生区域中增加，并且与幽门螺杆菌感染的十二指肠溃疡患者十二指肠中的CD4〜+ T细胞聚集有关
3. NOD1 is required for Helicobacter pylori Helicobacter pyloriHelicobacter pylori induction of IL‐33 responses in gastric epithelial cells [J] . Tran Le Son, Tran Darren, De Paoli Amanda, Cellular microbiology . 2018,第5期

机译：幽门螺杆菌幽门螺杆菌幽门螺杆菌诱导胃上皮细胞IL-33反应的幽门螺杆菌诱导幽门螺杆菌诱导
4. Expression of Suppressors of Cytokine Signaling-3 in Helicobacter pylori-Infected Rat Gastric Mucosal RGM-1 Cells [C] . BORAM CHA, KYUNG HWAN KIM, HIROFUMI MATSUI, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：细胞因子信号传导抑制剂3在幽门螺杆菌感染的大鼠胃粘膜RGM-1细胞中的表达
5. Gastric epithelial cells act as antigen -presenting cells (APCs): Relevance to Helicobacter pylori infection [D] . Barrera Zamora, Carlos Alberto 2001

机译：胃上皮细胞充当抗原呈递细胞（APC）：与幽门螺杆菌感染的相关性
6. Safety and Immunogenicity of Oral Inactivated Whole-Cell Helicobacter pylori Vaccine with Adjuvant among Volunteers with or without Subclinical Infection [O] . Karen L. Kotloff, Marcelo B. Sztein, Steven S. Wasserman, 2001

机译：带有或不带有亚临床感染的志愿者中口服佐剂全细胞灭活幽门螺杆菌疫苗的安全性和免疫原性
7. Safety and Immunogenicity of Oral Inactivated Whole-Cell Helicobacter pylori Vaccine with Adjuvant among Volunteers with or without Subclinical Infection [O] . Kotloff, Karen L., Sztein, Marcelo B., Wasserman, Steven S., 2001

机译：带有或不带有亚临床感染的志愿者中口服佐剂全细胞灭活幽门螺杆菌疫苗的安全性和免疫原性

B cell responses in gastric antrum and duodenum following oral inactivated Helicobacter pylori whole cell (HWC) vaccine and LTR192G in H-pylori seronegative individuals

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