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首页> 外文期刊>Vaccine >Effect of allergen-specific immunotherapy on plasma level of platelet factor 4 (PF-4) and beta-thromboglobulin (beta-TG), platelet activation markers in patients with house dust mite allergy
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Effect of allergen-specific immunotherapy on plasma level of platelet factor 4 (PF-4) and beta-thromboglobulin (beta-TG), platelet activation markers in patients with house dust mite allergy

机译：过敏原特异性免疫疗法对屋尘螨过敏患者血浆血小板因子4（PF-4）和β-血栓球蛋白（β-TG），血小板活化标志物的影响

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Patients suffering form house dust mite-sensitive persistent allergic rhinitis (PAR) seem to show changed platelet aggregability following mite allergen-specific immunotherapy (SIT). However, in patients with grass pollen-sensitive intermittent allergic rhinitis, platelet release reaction in vivo, measured by beta-TG, did not change significantly during the dose increase phase of subcutaneous SIT with grass pollen allergoids. The aim of this study was to evaluate the influence of SIT with house dust mite allergen extracts on the degree of circulating platelet activity in patients with PAR. The study comprised 14 patients sensitized to house dust mite allergens with PAR during the early phase of subcutaneous SIT with house dust mite allergen extracts-Dermatophagoides farinae 50 p.c. and Dermatophagoides pteronyssinus 50 p.c. (Novo-Helisen((R)) Depot, Allergopharma, Germany). SIT comprised subcutaneous injection of allergen extracts during approximately 3 months. Blood was collected before SIT, as well as immediately before, 30min and 24h after maximum dose injection. Plasma levels of PF-4 and beta-TG, platelet activation markers were measured using commercial ELISA kit. PF-4 and beta-TG basal levels were not significantly different between the patients and the healthy subjects. PAR patients treated with SIT showed no significant differences in plasma levels of the markers between the different points of the study. Thus, it seems that the degree of platelet activation measured by PF-4 and beta-TG does not change in PAR patients during hyposensitization with mite allergen extracts, after the maximum dose was reached.
机译：患有屋尘螨敏感的持续性变应性鼻炎（PAR）的患者似乎表现出针对螨虫变应原的免疫疗法（SIT）后血小板凝集力的变化。但是，在对草花粉敏感的间歇性变应性鼻炎患者中，通过β-TG测定的体内血小板释放反应在与草花粉变态反应物的皮下SIT剂量增加阶段没有明显变化。这项研究的目的是评估室内尘螨过敏原提取物对SIT对PAR患者循环血小板活性的影响。该研究包括14名在皮下SIT早期对室内尘螨过敏原致敏的PAR患者，室内皮螨过敏原提取物为粉尘螨Dermatophagoides farinae 50 p.c.和peronyophagoides pteronyssinus p.c. 50 （德国Allergopharma的Novo-Helisen（R）仓库）。 SIT包括在大约3个月内皮下注射变应原提取物。在SIT之前，最大剂量注射之前，30min和24h之前以及之后立即收集血液。使用市售ELISA试剂盒测量血浆PF-4和β-TG，血小板活化标记物的水平。患者和健康受试者之间的PF-4和β-TG基础水平无显着差异。用SIT治疗的PAR患者在研究的不同点之间血浆标志物水平无明显差异。因此，在达到最大剂量后，在使用螨过敏原提取物进行超敏反应期间，PAR患者中由PF-4和β-TG测定的血小板活化程度似乎没有变化。

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